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Why Novartis is changing the name of its research labs
![novartis institutes for biomedical research Jonathan Wosen](https://www.statnews.com/wp-content/uploads/2022/01/jonathan-w-avatar-round-80x80.png)
By Jonathan Wosen Sept. 8, 2023
S wiss drugmaker Novartis’ research and development hub has a new name — and a new guiding strategy.
The hub, which is headquartered in Cambridge, Mass., and for years has been known as Novartis Institutes for BioMedical Research, or NIBR, will soon simply be known as Novartis Biomedical Research.
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But that’s not the only thing that’s changing, Fiona Marshall, the hub’s president, told a virtual audience Thursday during the 2023 STAT Future Summit . The new name reflects a larger shift by the pharma giant to retool its research strategy — from one driven by the pure pursuit of scientific discovery to a tighter focus on projects likely to yield commercially successful drugs.
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Novartis Institutes for BioMedical Research is Novartis global research organization and is committed to discovering innovative medicines that cure disease and improve human health. By conducting more relevant and predictable drug discovery that can yield new and better medicines for patients, Novartis Institutes for BioMedical Research is redefining drug discovery in the post-genomic era. Over the past four years, Novartis Pharmaceuticals has had the greatest number of new molecular entities approved by the US FDA. With its broad focus on diseases for which there is a need for better medical therapies, and with 3,000 talented, dedicated research scientists worldwide, Novartis Institutes for BioMedical Research is well-positioned to ensure Novartis maintains its strong pipeline and highly successful track record in new drug discovery.> Novartis Institutes has sites in Cambridge, Massachusetts (headquarters); Basel, Switzerland; Horsham, UK; East Hanover, NJ; Vienna, Austria; and Tsukuba, Japan. Novartis Institutes Cambridge facilities encompass 750,000 square feet of laboratory and office space. Research in cardiovascular disease, oncology, infectious disease, diabetes, ophthalmology and skeletal muscle disease is headquartered in Cambridge. In addition, Cambridge is home to the following platform technologies: Global Discovery Chemistry, Functional Genomics, Developmental & Molecular Pathways, and Models of Disease Center.
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Novartis Institutes for BioMedical Research Cambridge Campus
An innovation engine for biomedical breakthroughs
Located at the heart of the Boston area innovation ecosystem, the Novartis Institutes for BioMedical Research (NIBR) complex is transforming the way scientists perform their ground-breaking work. Known as the innovation engine of the global Novartis organization, the NIBR is tasked with discovering new medicines for some of the most challenging health issues in the world.
Once located in disparate locations, the multi-building campus brings more than 1,000 top researchers together to spur increased collaboration, idea-sharing and teamwork. Novartis is using this complex to create a new paradigm—one that creates a dynamic workplace that breaks down the walls between disciplines, both figurative and literal, blurs the boundaries between discovery and commercialization, bridges geographies, and fundamentally changes its approach to science.
Maya Lin designed the overall masterplan and the building known as 181 Massachusetts Avenue. Toshiko Mori designed the second building, 22 Windsor Street, and Michael Van Valkenburgh designed the expansive courtyard. CannonDesign served as the architect of record, science/laboratory design firm, and design engineer for the entire complex.
Enhancing the new scientific workplace
The Novartis complex challenges what the traditional research model functions and looks like through unique design solutions, from the design aesthetic found throughout to the enriched laboratory environments, and the highest focus on sustainability, culture and community.
One of the design goals for the project was to present the buildings as penetrable to pedestrians and responsive to the surrounding context. Rather than build one massive structure, the complex consists of a community of buildings demonstrating that functional labs can be housed within beautiful and inspirational architecture.
Designed for research
Throughout the new research buildings, occupants encounter an overwhelming sense of openness. Expansive windows offer framed views of the outside, and voluminous atriums and open stairways span the height of the buildings. Knowing that teamwork and “heads down” work can take place in many settings, multiple workplace modes and venues are found throughout—from a 350-seat auditorium and large conference rooms to intimate huddle spaces, workstations, lounges and communal areas.
In the laboratories, collaboration is promoted by eliminating overhead casework and barriers between researchers; sightlines are clear and the equipment typically found cluttering benchtops is housed in centralized areas called Tech Zones. A just-in-time delivery system ensures researchers have the tools they need, and breakout rooms are incorporated into most laboratory environments to prevent researchers from having to leave the lab to work together.
Sustainably developed
The overall site dramatically improves the connection between Central Square and the Charles River by filling a once-barren strip of asphalt and concrete with dynamic uses and landscaping. Green roofs, storm water collection and reuse, external shading, sustainable materials, high-efficiency lab equipment and engineering systems, and more helped the project achieve LEED Gold certification. Taking a "whole building" approach to sustainability, the research complex is compliant with the EPA’s Labs21 Environmental Performance Criteria 2.0.
Community impact
To strengthen its role as a good civic neighbor, the building employs a number of features focused on positive community impact. The 1.35-acre courtyard at the center of the complex creates a diagonal pedestrian shortcut across the site and a publicly accessible campus-like environment filled with trees, seating and meandering pathways. Glass walls at the street level enhance the interaction between the buildings and the public, and more than 8,000 square feet of retail space welcomes pedestrians inside. On the ground floor of 22 Windsor Street, a Community Exploration and Learning Lab is dedicated to engaging middle and high school students in biomedical science.
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The Diabetes Genetics Initiative combines the resources and expertise of the Novartis Institutes for BioMedical Research, the Broad Institute of MIT and Harvard, and Lund University to identify the genetic determinants of type 2 diabetes. This unique collaboration aims to collect and analyze samples from type 2 diabetic patients from nations across the globe, performing whole genome scans to provide a comprehensive view of the DNA sequence variants associated with the disease. This partnership has been forged with the explicit goal of making this vast amount of crucial data available to researchers globally and free of cost, which should lead to a greater understanding of disease biology and speed the development of more effective therapies.
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Whole genome scan for type 2 diabetes in a Scandinavian cohort
The goal of this project is to identify inherited risk factors that predispose individuals to type 2 diabetes by performing a whole genome association study in approximately 3,000 individuals from Scandinavia, using the Affymetrix Human Mapping 500K GeneChip®.
Publication in Science : Genome-wide search unearths surprising clues for diabetes and blood triglycerides (04/26/07)
DIAGRAM Consortium: Results from type 2 diabetes meta-analysis Zeggini E, Scott LJ, Saxena R, Voight BF for the DIAGRAM consortium. Meta-analysis of genome-wide association data and large-scale replication identifies several additional susceptibility loci for type 2 diabetes. Nature Genetics in press.
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The goal of this project is to identify chromosomal loci linked to diabetes in three Scandinavian families with clustering of early-onset diabetes using the Affymetrix Human Mapping 500K GeneChip® (10,116 SNPs).
A whole genome admixture scan for type 2 diabetes in African Americans
The goal of this project is to perform a whole genome admixture scan in 1,976 African Americans from the Jackson Heart Study and the Multi-Ethnic Cohort, aiming to localize susceptibility loci for type 2 diabetes.
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- Published: 30 March 2017
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Nature Reviews Drug Discovery volume 16 , pages 232–233 ( 2017 ) Cite this article
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An Erratum to this article was published on 18 April 2017
This article has been updated
In 2015, the haematologist Jay Bradner made the leap from supervising a few dozen researchers in his lab at the Dana-Farber Cancer Institute to overseeing more than 6,000 scientists at Novartis. As president of the Novartis Institutes for BioMedical Research (NIBR), he has now rolled out his vision for NIBR 2.0 — with an increased focus on chemical biology and open science. He spoke with Asher Mullard about his plans to restructure around emerging drug discovery tools and to forge closer ties with the rest of the scientific community.
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Toshiko Mori and Maya Lin create buildings for Boston pharmaceutical campus
Architects Toshiko Mori , Maya Lin and CannonDesign teamed up to design this new research complex for Swiss drug company Novartis, located in the Boston area.
The complex, called the Novartis Institutes for BioMedical Research, is located on a busy street in Cambridge, near the campus for the Massachusetts Institute of Technology . Encompassing more than 800,000 square feet (74,322 square metres), the complex brings together over 1,000 pharmaceutical researchers.
![novartis institutes for biomedical research Novartis Institute in Cambridge](https://static.dezeen.com/uploads/2017/05/novartis-institutes-biomedical-research-cambridge-campus-cannon-design-architecture-education-boston-usa_dezeen_2364_col_2.jpg)
"The overarching goal for the project was to create an ideal work environment for research, with specific emphasis on increasing the exchange of knowledge and levels of interdisciplinary collaboration," said US-based CannonDesign , which served as the project’s architect of record.
The urban complex consists of two connected buildings, which wrap a courtyard designed by Michael Van Valkenburgh Associates , a Brooklyn -based landscape architecture firm. An underground parking garage is hidden beneath.
![novartis institutes for biomedical research Novartis Institute in Cambridge](https://static.dezeen.com/uploads/2017/05/novartis-institutes-biomedical-research-cambridge-campus-cannon-design-architecture-education-boston-usa_dezeen_2364_col_1.jpg)
Occupying one corner of the campus is the 181 Massachusetts Avenue building, conceived by designer Maya Lin in association with New York architecture firm Bialosky + Partners Architects .
L-shaped in plan, the building consists of two distinct volumes: a tall, rectilinear portion that contains laboratories, and a lower, curved portion that houses offices, meetings rooms, and an auditorium.
![novartis institutes for biomedical research Novartis Institute in Cambridge](https://static.dezeen.com/uploads/2017/05/novartis-institutes-biomedical-research-cambridge-campus-cannon-design-architecture-education-boston-usa_dezeen_2364_col_4.jpg)
"The design of the building maintains the human scale of the adjacent buildings at street level while creating a taller space for research labs set back from the street," Lin explained on her studio's website .
The lower portion is wrapped with a distinctive screen made of light-coloured stone. Its appearance was inspired by "microscopic views of organic coral or bone structure".
![novartis institutes for biomedical research Novartis Institute in Cambridge](https://static.dezeen.com/uploads/2017/05/novartis-institutes-biomedical-research-cambridge-campus-cannon-design-architecture-education-boston-usa_dezeen_2364_col_5.jpg)
The curtain wall behind the screen is composed of five different hues of glass that mathematically correspond to the openings in the stone brise-soleil.
"Conceptually I felt this translation of nature through a systematic and mathematical process reflects back on how science and medicine take materials found in nature and, through scientific analysis and research, transform them into new medicinal compounds," Lin stated.
![novartis institutes for biomedical research Novartis Institute in Cambridge](https://static.dezeen.com/uploads/2017/05/novartis-institutes-biomedical-research-cambridge-campus-cannon-design-architecture-education-boston-usa_dezeen_2364_col_9.jpg)
Lin’s building is linked to 22 Windsor Street, a research facility designed by Toshiko Mori 's New York studio – whose impressive portfolio includes a cultural centre in Senegal and an extension to a Marcel Breuer-designed house .
Rectangular in plan, the glazed building features glass louvres with copper mesh interlayers, which help shade sensitive laboratory zones. On the southern facade, protrusions framed in stone denote communal areas.
![novartis institutes for biomedical research Novartis Institute in Cambridge](https://static.dezeen.com/uploads/2017/05/novartis-institutes-biomedical-research-cambridge-campus-cannon-design-architecture-education-boston-usa_dezeen_2364_col_6.jpg)
"Social spaces are expressed by large stone frames, enlivening the southern facade in a dialogue with the campus, community and city," states a description on Mori’s website .
For the interior of the two buildings, the team focused on creating flexible spaces with minimal columns and broad sight lines. "Specialised functions and tech zones are grouped around core laboratory equipment to further eliminate visual obstacles in the labs," said CannonDesign.
![novartis institutes for biomedical research Novartis Institute in Cambridge](https://static.dezeen.com/uploads/2017/05/novartis-institutes-biomedical-research-cambridge-campus-cannon-design-architecture-education-boston-usa_dezeen_2364_col_8.jpg)
To help inform the interior design, the team created a full-scale, experimental mockup in a nearby vacant space to test new organisational and physical models.
"This resulted in research environments that were applied to this complex, as well as to many other existing Novartis research facilities worldwide," the team said.
Photography is by Esto Photographics Inc and Anton Grassl.
Project credits:
Design architect for 181 Massachusetts Avenue: Maya Lin Studio with Bialosky + Partners Architects Design architect for 22 Windsor Street: Toshiko Mori Architect Architect of record, structural engineering and MEP: CannonDesign Landscape architect: Michael Van Valkenburgh Associates Engineering: Nitsch Engineering Contractor: Skanska USA Building Inc
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Your Key Responsibilities:
• Actively participate in scientific discussions, performing critical review of experimental protocols and identifying the best approach for in vivo studies according to project needs. • Schedule, perform and coordinate state-of-the-art animal experimentation and data interpretation with the highest ethical and technical standards, setting up and validating animal models independently and/or together with BR scientific project teams. • High level technical expertise with experience in developing novel animal models (Rodent and USDA species). • Be an excellent team player and show potential to lead associates, ensuring appropriate performance, training, and professional development of the associates. Identify and coach high and low performers (leadership experience advantageous) • Responsible for ensuring team compliance with all institutional and regulatory protocols, policies, and guidelines.
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Some weekend on call, holiday coverage required. • Bachelor or Master’s in Biomedical Sciences or equivalent experience, • Minimum 5+ years of experience in a technical skills tract laboratory animal program • Strong commitment to animal welfare, research support, and high quality in vivo focused science • Strong communication with a broad range of stakeholders, strong aptitudes as team player. • Strong leadership skill base and prior experience of leading a small team of research associates, preferred. • Responsible for pursuing continuous learning/professional development opportunities, enhancing/expanding skill set, and reviewing CM techniques. • Fluency in English. • Must be able to lift 50 lbs., be able to work from a standing position for prolonged periods of time and perform repetitive motion tasks.
Commitment to Diversity & Inclusion: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $97,600- $146,400/year ; however, w hile salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors
Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture
Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network
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Learn about Novartis' biomedical research engine that powers an industry-leading pipeline of innovative medicines for various diseases. Explore the research areas, technology platforms, clinical trials, collaborations and stories of Novartis' biomedical research.
The Novartis Institutes for BioMedical Research (NIBR) give students the opportunity to gain real-world disease research experience at a global biotech company.
The hub, which is headquartered in Cambridge, Mass., and for years has been known as Novartis Institutes for BioMedical Research, or NIBR, will soon simply be known as Novartis Biomedical Research.
Read how scientists in the Oncology Disease Area at the Novartis Institutes for BioMedical Research (NIBR) are exploring novel approaches for fighting cancer.
Overview Novartis Institutes for BioMedical Research is Novartis global research organization and is committed to discovering innovative medicines that cure disease and improve human health. By conducting more relevant and predictable drug discovery that can yield new and better medicines for patients, Novartis Institutes for BioMedical Research is redefining drug discovery in the post-genomic ...
Shiva Malek, Global Head of Oncology at Novartis Institutes for BioMedical Research, shares her personal and professional journey in cancer drug discovery. She discusses the role of science, serendipity, innovation and patient needs in her work.
Find 677 researchers and browse 11 departments, publications, full-texts, contact details and general information related to Novartis Institutes for BioMedical Research | Cambridge, Switzerland | NIBR
Shiva Malek, head of oncology at Novartis Institutes for Biomedical Research, discusses her ambitions and challenges in developing new drugs for cancer. She covers topics such as transcription factors, drug resistance, radioligand therapies and cell therapies.
The Novartis Institutes for BioMedical Research PDX encyclopedia (NIBR PDXE) A total of 1,075 PDX models across the spectrum of common adult solid cancers were established ( Fig. 1a ).
The articles listed below published by authors from Novartis Institutes for Biomedical Research (NIBR), organized by journal and article, represent the research output in Count and Share according ...
Novartis uses chemical biology to develop new molecules and probe biological systems for drug discovery. The Biomedical Research unit collaborates with internal and external partners to tackle difficult targets and advance science for patients.
Located at the heart of the Boston area innovation ecosystem, the Novartis Institutes for BioMedical Research (NIBR) complex is transforming the way scientists perform their ground-breaking work. Known as the innovation engine of the global Novartis organization, the NIBR is tasked with discovering new medicines for some of the most challenging health issues in the world.
The company's global research operations, called "Novartis Institutes for BioMedical Research (NIBR)" have their global headquarters in Cambridge, Massachusetts, United States. [141][142] Two research institutes reside within NIBR that focus on diseases in the developing world: Novartis Institute for Tropical Diseases, which works on ...
Overall Count and Share for 'Novartis Institutes for Biomedical Research (NIBR)' based on the 12-month time frame mentioned above.
The Novartis Global Scholars Program (NGSP) is a competitive program that funds innovative projects from invited institutions to advance drug discovery and clinical research. NGSP scholars receive up to 1 mil USD funding and access to inter-disciplinary expertise from Novartis Biomedical Research scientists.
The Diabetes Genetics Initiative combines the resources and expertise of the Novartis Institutes for BioMedical Research, the Broad Institute of MIT and Harvard, and Lund University to identify the genetic determinants of type 2 diabetes. This unique collaboration aims to collect and analyze samples from type 2 diabetic patients from nations across the globe, performing whole genome scans to ...
Genomics Institute of the Novartis Research Serves as a bridge between basic science and preclinical drug discovery for Novartis' global research organization, the Novartis Institutes for BioMedical Research (NIBR).
Novartis Institutes for BioMedical Research (NIBR) NIBR is the global pharmaceutical research organization of Novartis. With approximately 6,000 scientists and physicians around the world, our research is focused on discovering innovative new drugs that will change the practice of medicine. We have an open and entrepreneurial culture, encouraging collaboration to make effective therapies. We ...
Jay Bradner, President of the Novartis Institutes for BioMedical Research, discusses increased interest in chemical biology and open science at Novartis.
The complex, called the Novartis Institutes for BioMedical Research, is located on a busy street in Cambridge, near the campus for the Massachusetts Institute of Technology. Encompassing more than ...
Fiona Marshall, Ph.D., joins Novartis from Merck to lead the Novartis Institutes for BioMedical Research (NIBR), effective November 1, 2022. She replaces Jay Bradner, M.D., who steps down from the Executive Committee of Novartis after seven years as NIBR President.
PURPOSE BT5528 is a Bicycle Toxin Conjugate, a novel class of chemically synthesized molecules, comprising a bicyclic peptide targeting EphA2 tumor antigen, linked to a cytotoxin (monomethyl auristatin E [MMAE]). EphA2 is overexpressed in many solid tumors and contributes to oncogenesis, tumor-associated angiogenesis, and metastasis. MATERIALS AND METHODS The primary objectives were to ...
Research Collaborations (RC) is a centralized core unit within In vivo Science & Technology (IST), Comparative Medicine (CM). RC is responsible for performing best-in-class in-vivo studies together with developing key animal models and cutting-edge technologies needed for Biomedical Research (BR) drug discovery and development process.