research paper on genetic technology

In 1987, the New York Times Magazine characterized the Human Genome Project as the "biggest, costliest, most provocative biomedical research project in history." 2 But in the years between the ...

Developments in all fields of genetics and genetic technology in the first half of the 20th century provided a basis for the later developments. In the second half of the 20th century, the molecular background of genetics has become more understandable. Rapid technological advancements, followed by the completion of Human Genome Project, have ...

Introduction. Gene therapy is a therapeutic strategy using genetic engineering techniques to treat various diseases. 1, 2) In the early 1960s, gene therapy first progressed with the development of recombinant DNA (rDNA) technology, 1) and was further developed using various genetic engineering tools, such as viral vectors. 3 - 5) More than ...

The past decade has witnessed the discovery, engineering, and deployment of RNA-programmed genome editors across many applications. By leveraging CRISPR-Cas9's most fundamental activity to create a targeted genetic disruption in a gene or gene regulatory element, scientists have built successful platforms for the rapid creation of knockout mice and other animal models, genetic screening, and ...

The rapid advances in genetic technology make this debate very topical. Moreover, genes are thought to play a very substantial role in biological evolution and development of the human species, thus making this a topic requiring due consideration. With this commentary, we explore how concepts based in evolutionary biology could contribute to ...

Genetic engineering is the use of molecular biology technology to modify DNA sequence(s) in genomes, using a variety of approaches. For example, homologous recombination can be used to target specific sequences in mouse embryonic stem (ES) cell genomes or other cultured cells, but it is cumbersome, poorly efficient, and relies on drug positive/negative selection in cell culture for success.

Genetic engineering articles from across Nature Portfolio. Genetic engineering is the act of modifying the genetic makeup of an organism. Modifications can be generated by methods such as gene ...

PERSPECTIVE 3 human molecular genetics and genomics n engl j med 384;1 nejm.org January 7, 2021 The discovery of genes responsi-ble for more than 5000 rare

Genetic engineering has provided humans the ability to transform organisms by direct manipulation of genomes within a broad range of applications including agriculture (e.g., GM crops), and the ...

Scientific Reports 12, Article number: 20497 ( 2022 ) Cite this article. Recent advances in genome editing technologies have redefined our ability to probe and precisely edit the human genome and ...

Moreover, technology casts its transformative shadow across a plethora of domains, from cancer research and regenerative medicine to environmental conservation [97]. The success of utilizing CRISPR-Cas9 for genetic editing and therapeutic applications relies heavily on the effective delivery of its components into target cells.

Genome-wide editing is not a new field, and in fact, research in this field has been active since the 1970s. The real history of this technology started with pioneers in genome engineering [36, 59].The first important step in gene editing was achieved when researchers demonstrated that when a segment of DNA including homologous arms at both ends is introduced into the cell, it can be ...

In this paper, the analysis of recent advances in genetic algorithms is discussed. The genetic algorithms of great interest in research community are selected for analysis. This review will help the new and demanding researchers to provide the wider vision of genetic algorithms. The well-known algorithms and their implementation are presented with their pros and cons. The genetic operators and ...

Genetic engineering (GE) is often termed as gene manipulatio n or recombinant DNA technology with all. three often used interchangeably -- implying to t he m anipulation and alteration of the ...

Genetic modification of living organisms has been a prosperous activity for research and development of agricultural, industrial and biomedical applications. Three decades have passed since the first genetically modified products, obtained by transgenesis, become available to the market. The regulatory frameworks across the world have not been able to keep up to date with new technologies ...

Introduction. The past two decades have seen major shifts in our technical ability to sequence genetic information at scale. Historically, genetic testing tended to consist of either highly detailed molecular testing of nominated single genes, or broad genome-wide dosage screening at low resolution, for example karyotyping [1,2].Genome sequencing was too slow and too expensive to be used in ...

Manar A. Basheer, Khaled Abutaleb, Nermine N. Abed and Amal A. I. Mekawey. Journal of Genetic Engineering and Biotechnology 2023 21 :127. Research Published on: 21 November 2023. The Correction to this article has been published in Journal of Genetic Engineering and Biotechnology 2023 21 :164. Full Text.

This Special Issue of Plants is a continuation of numerous optimistic applications of genomics to enhance food crop production, based on detailed knowledge of genetic structure and its intergenomic interactions not observed in food production environments. Genomics can provide important data for food production in three ways. First, genomics can be utilized as an important element in breeding ...

Genetic engineering refers to the specific molecular biological modification of DNA sequences. With the rapid development of genetic engineering methods, especially the breakthroughs in guiding endonuclease technology, gene remodeling of crops has become simpler, more precise, and efficient. Genetic engineering techniques can be used to develop crops with superior traits such as high trace ...

Genetic modification in plants was first recorded 10,000 years ago in Southwest Asia where humans first bred plants through artificial selection and selective breeding. Since then, advancements in agriculture science and technology have brought about the current GM crop revolution. GM crops are promising to mitigate current and future problems ...

European Journal of Human Genetics - Recent developments in genetics and medically assisted reproduction: from research to clinical applications ... As soon as there is proven laboratory ...

1.Introduction. Community genetics is a synthesis between community ecology and population genetics. One key goal of community genetics is to identify how intraspecific genetic variation affects and/or responds to community ecological properties and the factors that drive associations between population genetic variation and community species variation (Antonovics et al., 2003; Johnson and ...

A quick approach is offered by recombinant DNA technology to scrutinize the genetic expression of the mutations that were introduced into eukaryote genes through cloned insulin genes insertion inside a simian virus fragment . In a similar way, tumor growth was inhibited by adenoviral vector that encodes endostain human secretory form through ...

REJECTING GENETIC DETERMINISM ABOUT SOCIAL BEHAVIOR. This leads us to our second concern, that McMahan and Savulescu over-emphasize the connection between genetics and social behavior through their use of pleiotropy. In their main example, parents are given a choice to edit-out or leave-in a gene responsible for creativity that is linked to bipolar depression (BPD).

The granted patent US12046327B1 outlines a method and system for determining genetic relatedness between individuals using a services platform. The process begins with the platform determining a "focal string" based on personal information of a focal individual and retrieving a "reference string" from a reference database.

2. CONSTANTLY UPDATED GENOME‐EDITING TECHNOLOGY. In the 1980s, restriction endonuclease from bacteria was used to cleave the DNA double helix. 1 Since then, scientists have made a great effort to enrich the genome‐editing arsenal to manipulate gene sequences at specific loci. Different classes of genome manipulation tools are currently exploited for multiple applications in laboratory ...

Modern technology has enabled police to identify a woman found dead near a picnic area east of Guelph almost 20 years ago as a missing British Columbia woman. On Aug 28, 2005, a deceased female ...