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Biomedical Engineering: Research & Writing
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- A+Research and Writing Guide . Provides a step-by-step guide to writing a research paper, research methodology and resources, and links to OWLS (Online Writing Labs) that provide guides to specific types of papers and essays (e.g., argumentative, narrative, comparative).
- The Nuts and Bolts Guide to College Writing - a very good source for all aspects of writing, including the mechanics of grammar, types of papers, and citation formats (APA, MLA, and Chicago).
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BMC Biomedical Engineering: a home for all biomedical engineering research
Alexandros houssein.
1 Springer Nature, 4 Crinan Street, London, N1 9XW UK
Alan Kawarai Lefor
2 Department of Surgery, Jichi Medical University, Shimotsuke, Tochigi Japan
Antonio Veloso
3 Laboratory of Biomechanics and Functional Morphology, Faculty of Human Kinetics, Lisbon, Portugal
4 Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN USA
Jong Chul Ye
5 Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
Dimitrios I. Zeugolis
6 Regenerative, Modular and Developmental Engineering Laboratory (REMODEL), Biomedical Sciences Building, National University of Ireland Galway (NUI Galway), Galway, Ireland
Sang Yup Lee
7 Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
Associated Data
Not applicable.
This editorial accompanies the launch of BMC Biomedical Engineering , a new open access, peer-reviewed journal within the BMC series, which seeks to publish articles on all aspects of biomedical engineering. As one of the first engineering journals within the BMC series portfolio, it will support and complement existing biomedical communities, but at the same time, it will provide an open access home for engineering research. By publishing original research, methodology, database, software and review articles, BMC Biomedical Engineering will disseminate quality research, with a focus on studies that further the understanding of human disease and that contribute towards the improvement of human health.
Introduction
Biomedical engineering is a multidisciplinary field that integrates principles from engineering, physical sciences, mathematics and informatics for the study of biology and medicine, with the ultimate goal of improving human health and quality of life.
Biomedical engineering is not a new concept; however, it was not until the 1900s when rapid technological advancements in the chemical, physical and life sciences influenced breakthroughs in the prevention, diagnosis and treatment of disease. The invention of the electrocardiograph, the concept of x-ray imaging, the electron microscope, the mechanical heart valve and human genome sequencing, are just a few examples of technological innovations that revolutionised science and medicine and changed the approach to human healthcare. Current biomedical engineering technologies are a growing part of clinical decision making, which can now be influenced from multiscale observations, ranging from the nano to the macro-scale.
Today, the need for innovation in health technologies is ever more prominent. The annual global healthcare spending has seen continued growth and is projected to reach a staggering $8.7 trillion by 2020 [ 1 ]. Global health challenges are becoming more complex, wide spread and difficult to control. Resources are scarce and with a growing population, our society has a need for affordable, portable and sustainable solutions. The World Health Organisation has pledged to make a billion lives healthier by 2023 [ 2 ], a goal that will require widespread commitment by governments, funding agencies, researchers and clinicians. Biomedical engineers will be at the heart of this movement and face a responsibility for continuous innovation. Biomedical engineering research is expected to create health technologies that will drastically improve the prevention, diagnosis and treatment of disease, as well as patient rehabilitation. As an example, the NIH 2016–2020 strategic plan focuses on point of care and precision medicine technologies including genetic engineering, microfluidics, nanomedicine, imaging, digital/mobile-Health and big data [ 3 ].
BMC Biomedical Engineering will strive to complement these efforts and provide an open access venue for the dissemination of all biomedical engineering research. As part of the BMC series, a portfolio of journals serving communities across all sciences, the Journal will act as a resource for a wide range of disciplines. It aims to support scientists, engineers and clinicians by making their research openly and permanently available, irrespective of their location or affiliation.
Aims and scope
BMC Biomedical Engineering considers articles on all aspects of biomedical engineering, including fundamental, translational and clinical research. It combines tools and methods from biology and medicine with mathematics, physical sciences and engineering towards the understanding of human biology and disease and the improvement of human health. The Journal will publish a range of article types, including research, methodology, software, database and review articles.
As part of the BMC series, a collection of open access, peer-reviewed and community focused journals covering all areas of science, editorial decisions will not be made on the basis of the interest of a study or its likely impact. Studies must be scientifically valid. For research articles this includes a scientifically sound research question, the use of suitable methods and analysis, and following community-agreed standards relevant to the research field.
BMC Biomedical Engineering aims to publish work that undergoes a thorough peer review process by appropriate peer-reviewers and is deemed to be a coherent and valid addition to the scientific knowledge. It aims to provide an open access venue which allows for immediate and effective dissemination of research and enables our readers to explore and understand the latest developments, trends and practices in biomedical engineering. We believe that open access and the Creative Commons Attribution License [ 4 ] are essential to this, allowing universal and free access to all articles published in the Journal and allowing them to be read and the data re-used without restrictions. BMC Biomedical Engineering will work closely with the rest of the journals in the BMC series portfolio [ 5 ] to help authors find the right home for their research. We will highlight selected journal content through various promotional channels to ensure the research reaches its target audience and receives the attention it deserves.
Editorial sections
Many new technologies that have revolutionised biomedical engineering require the coalition of previously independent communities. 3D bioprinting of tissues and organs brings together methods from cell biology, biomaterials, nanotechnology and engineering and is being used for the transplantation of tissues, including skin, bone, muscle, soft tissue, cartilage and others [ 6 , 7 ]. The concept of tissue and disease modelling is being driven towards drug discovery and toxicology studies, aiming to increase the yield of drug testing by tackling limitations of current cell and animal models [ 8 ].
New approaches in natural and synthetic biomaterials have redefined bioelectronics. Silk fibroins and other unconventional interfaces can form flexible electronics and challenge the use of silicon-based technologies. For biomedical applications, these new approaches present advantages not only due to their biocompatibility and low cost, but also for their electromechanical and optical virtues [ 9 ]. Implantable probes are being redesigned so that they facilitate long term stability and high resolution, without perturbing the biological system or creating an immune response. Such technologies are now able to facilitate recordings of single neurons in vivo, in a chronically stable manner, with applications to the restoration of vision and retinal prosthetics [ 10 ].
For many years biomedical imaging has been connecting microscopic discoveries with macroscopic observations. Photoacoustic tomography (PAT) is now able to image large spatial scales, from organelles to small animals, at very high speeds [ 11 ]. In fact, single-shot real-time imaging can operate at 10 trillion frames per second and is finding applications in breast cancer diagnosis [ 12 , 13 ].
In the field of medical robotics, new approaches combine machine learning and artificial intelligence to strengthen the clinician’s decision making. Others are leveraging augmented reality (AR) to facilitate better immersion and more natural surgical workflows for computer assisted orthopaedic surgery [ 14 ].
BMC Biomedical Engineering celebrates the interdisciplinary nature of the field. In order to navigate the wide range of biomedical engineering research, the Journal is structured in six editorial sections.
- Biomaterials, nanomedicine and tissue engineering
- Medical technologies, robotics and rehabilitation engineering
- Biosensors and bioelectronics
- Computational and systems biology
- Biomechanics
- Biomedical Imaging
We are delighted to welcome our founding Section Editors along with a growing international group of Editorial board Members [ 15 , 16 ]. The Journal is supported by an expert Editorial Advisory group of senior engineers and scientists, which is chaired by Distinguished Professor Sang Yup Lee. Together with the in-house Editor, this group will provide academic leadership and expertise and will work together to transverse into multiple clinical and engineering disciplines. The Editorial Board will keep growing and developing to reflect and adapt to the nature of this diverse community.
Biomaterials, nanomedicine and tissue engineering section
This section primarily focuses on the development of biofunctional tissue substitutes, which possess the highest level of biomimicry, through recapitulation of nature’s innate sophistication and thorough processes. It considers research, methods, clinical trials, leading opinion and review articles on the development, characterisation and application of nano- and micro- biofunctional biomaterials, cell-assembled tissue substitutes, diagnostic tools, microfluidic devices and drug/gene discovery and delivery methods. Manuscripts focusing on permanently differentiated, engineered and stem cell biology and application are welcome. This section will place a substantial focus on clinical translation and technologies that advance the current status-quo. As such, articles that enhance the scalability and robustness of tissue engineering methodologies, or that enable new and improved industrial or clinical applications of biomedical engineering discoveries, tools and technologies are strongly encouraged.
Medical technologies, robotics and rehabilitation engineering section
This section seeks to represent research in engineering that encompasses a wide range of interests across medical specialties, including orthopaedic, cardiovascular, musculoskeletal, craniofacial, neurological, urologic and other medical technologies. It will consider research on medical robotics, computer assisted technologies, medical devices, e/m-health and other medical instrumentation. It aims to improve the prevention, diagnosis, intervention and treatment of injury or disease and it welcomes articles that represent new approaches to engineering that may be useful in the care of patients. Technical and practical aspects of rehabilitation engineering, from concept to clinic and papers on improving the quality of life of patients with a disability are encouraged. The section also seeks to represent clinically important research that is based on new and emerging technologies. This could include clinical studies of new approaches to robotic-assisted surgery, clinical studies of new devices, or other studies that are close to patient care or rehabilitation.
Biosensors and bioelectronics section
This section considers articles on the theory, design, development and application on all aspects of biosensing and bioelectronics technologies. The section will consider approaches that combine biology and medicine with sensing and circuits and systems technologies on a wide variety of subjects, including lab-on-chips, microfluidic devices, biosensor interfaces, DNA chips and bioinstrumentation. It also considers articles on the development of computational algorithms (such as deep learning, reinforcement learning, etc.) that interpret the acquired signals, hardware acceleration and implementation of the algorithms, brain-inspired or brain-like computational schemes, and bioelectronics technologies that can have a wide impact in the research and clinical community. Articles on implantable and wearable electronics, low-power, wireless and miniaturised imaging systems, organic semiconductors, smart sensors and neuromorphic circuits and systems are strongly encouraged.
Computational and systems biology section
Computational, integrative and systemic approaches are at the heart of biomedical engineering. This section considers papers on all aspects of mathematical, computational, systems and synthetic biology that result in the improvement of patient health. Integrative and multi-scale approaches, in the network and mechanism-based definition of injury and disease, or its prevention, diagnosis and treatment are welcome. Papers on high precision, interactive and personalised medicine, on digital/mobile health, on complex/big data analytics and machine learning, or on systemic and informatics approaches in a healthcare or clinical setting are encouraged.
Biomechanics section
This section represents the interdisciplinary field of biomechanics and investigates the relationship of structure with function in biological systems from the micro- to the macro- world. It considers papers on all aspects of analytical and applied biomechanics at all scales of observation, that improve the diagnosis, therapy and rehabilitation of patients or that advance their kinetic performance. The topics of interest range from mechanobiology and cell biomechanics to clinical biomechanics, orthopaedic biomechanics and human kinetics. Articles on the mechanics and wear of bones and joints, artificial prostheses, body-device interaction, musculoskeletal modelling biomechanics and solid/fluid computational approaches are strongly encouraged.
Biomedical imaging section
Biomedical imaging has been connecting microscopic discoveries with macroscopic observations for the diagnosis and treatment of disease and has seen considerable advances in recent years. This section will consider articles on all biomedical imaging modalities including medical imaging (MRI, CT, PET, ultrasound, x-ray, EEG/MEG), bio-imaging (microscopy, optical imaging) and neuroimaging across all scales of observation. Its primary focus will be to foster integrative approaches that combine techniques in biology, medicine, mathematics, computation, hardware development and image processing. Articles on new methodologies or on technical perspectives involving novel imaging concepts and reconstruction methods, machine learning, sparse sampling and statistical analysis tool development are encouraged.
The motivation for the launch of BMC Biomedical Engineering is to create an authoritative, unbiased and community-focused open access journal. We are committed to working together with our authors, editors and reviewers to provide an inclusive platform for the publication of high-quality manuscripts that span all aspects of biomedical engineering research. We welcome articles from all over the world and we will devote our efforts to ensure a robust and fair peer-review process for all. We believe in continuous improvement and we encourage the community to get in touch with us to provide ideas and feedback on how to improve the Journal and serve the community better.
We hope you will find the first group of articles an interesting and valuable read, and we look forward to working with you all to disseminate research into the exciting field of biomedical engineering.
Acknowledgements
Availability of data and materials, abbreviations.
AR | Augmented Reality |
CT | Computed Tomography |
EEG | Electroencephalogram |
MEG | Magnetoencephalography |
PAT | Photoacoustic Tomography |
PET | Positron Emission Tomography |
Authors’ contributions
AH wrote the introduction, aims and scope and conclusion. AH, AKL, AV, ZY, JCY, DIZ and SYL wrote the editorial sections. All authors read and approved the final version of the manuscript.
Ethics approval and consent to participate
Consent for publication, competing interests.
AH is the Editor of BMC Biomedical Engineering and an employee of Springer Nature. AL, AV, ZY, JY, DZ and SL are members of the Editorial Board of BMC Biomedical Engineering .
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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51 top topics for masters thesis in biomedical engineering.
Biomedical Engineering (BME) is the application of the principles and problem-solving techniques of engineering to biology and medicine. It focuses on the advances that improve human health and health care at all levels. It is evident throughout the healthcare, from diagnosis and analysis to treatment and recovery, and has entered the public conscience though the proliferation of implantable medical devices, such as artificial hips and pacemakers, to more futuristic technologies such as 3-D printing of biological organs and stem cell engineering.
How is Biomedical Engineering Different?
Biomedical Engineering is different from other engineering disciplines that have an influence on human health. It uses and applies an intimate knowledge of modern biological principles in their engineering design process. Aspects of electrical engineering, mechanical engineering, material science, chemical engineering, chemistry, mathematics, and computer science are all integrated with human biology in biomedical engineering to improve human health, whether it be an advanced prosthetic limb or a breakthrough in identifying proteins within cells.
Biomedical Engineering Sub-disciplines
There are many subdisciplines within biomedical engineering, including the design and development of active and passive medical devices, medical imaging, orthopedic implants, biomedical signal processing, tissue and stem cell engineering, and clinical engineering just to name a few.
If you are a masters student in Biomedical Engineering and looking for topics to write your masters thesis in Biomedical Engineering, here is a comprehensive list of 51 Biomedical Engineering Masters Thesis topics.
51 Best Masters Thesis Topics for Biomedical Engineering
- Development of a novel biosensor for early detection of cancer biomarkers.
- Design and optimization of drug delivery systems using nanotechnology for targeted therapy.
- Investigation of the biomechanics of joint replacement implants for improved longevity and performance.
- Development of a wearable device for continuous monitoring of vital signs in real-time.
- Optimization of imaging techniques for improved resolution and contrast in medical imaging.
- Design and fabrication of 3D-printed tissue scaffolds for regenerative medicine applications.
- Evaluation of the biocompatibility and long-term performance of implantable medical devices.
- Investigation of neural interfaces for brain-computer interfaces and prosthetic control.
- Development of a computational model for simulating physiological processes in the human body.
- Design of assistive technologies for individuals with disabilities, such as exoskeletons or robotic prostheses.
- Evaluation of the effects of electromagnetic fields on human health and safety.
- Development of point-of-care diagnostic devices for rapid and accurate detection of infectious diseases.
- Investigation of the biomechanical properties of soft tissues for improved surgical outcomes.
- Design and optimization of rehabilitation devices for physical therapy and rehabilitation.
- Development of advanced imaging techniques for non-invasive monitoring of tissue oxygenation.
- Evaluation of the effects of biophysical stimuli on cellular behavior and tissue regeneration.
- Design of smart materials for controlled drug release and tissue engineering applications.
- Investigation of the biomechanics of human gait and locomotion for improved prosthetic design.
- Development of bio-inspired materials and structures for tissue engineering and regenerative medicine.
- Optimization of microfluidic devices for applications in diagnostics, drug delivery, and tissue engineering.
- Investigation of the biocompatibility and immunogenicity of biomaterials for medical implants.
- Development of wearable sensors for monitoring and managing chronic diseases, such as diabetes or hypertension.
- Design and optimization of implantable biosensors for continuous monitoring of physiological parameters.
- Investigation of the effects of mechanical loading on bone remodeling and fracture healing.
- Development of computational models for predicting the behavior of biological systems under different conditions.
- Optimization of tissue culture techniques for the expansion and differentiation of stem cells.
- Investigation of the effects of aging on musculoskeletal function and mobility.
- Design and optimization of bioactive coatings for medical implants to improve tissue integration.
- Development of microfluidic systems for isolation and analysis of circulating tumor cells.
- Investigation of the biomechanics of the cardiovascular system for improved diagnosis and treatment of heart disease.
- Design of wearable technologies for monitoring and managing mental health conditions, such as anxiety or depression.
- Development of novel biomaterials for tissue engineering applications, such as cartilage or cardiac tissue regeneration.
- Investigation of the effects of environmental factors on human health and disease susceptibility.
- Optimization of imaging techniques for non-invasive assessment of tissue function and metabolism.
- Development of personalized medicine approaches for diagnosis and treatment of cancer.
- Investigation of the biomechanics of sports-related injuries and their prevention.
- Design and optimization of wearable devices for monitoring and enhancing athletic performance.
- Development of advanced imaging techniques for visualization of cellular and molecular processes in vivo.
- Investigation of the effects of exercise and physical activity on cardiovascular health and fitness.
- Design of assistive technologies for aging populations, such as mobility aids or home monitoring systems.
- Development of computational models for predicting the response of tissues to mechanical stimuli.
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- Matlab Solutions for Biomedical Engineering Assignments
Biomedical Engineering Applications: Matlab Solutions for Assignments
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Matlab, short for Matrix Laboratory, stands as a cornerstone tool in the realm of biomedical engineering, offering an array of functionalities crucial for tackling the complex challenges inherent to this interdisciplinary field. With its versatile capabilities in numerical computing, data analysis, and visualization, Matlab serves as a vital instrument empowering biomedical engineers to unravel the intricacies of biological systems, innovate medical technologies, and enhance healthcare outcomes. There are numerous resources available to help you navigate its powerful capabilities for biomedical engineering applications.
In the realm of biomedical engineering, Matlab's significance reverberates across various domains, including but not limited to image processing, signal analysis, modeling, and data visualization. Its robust suite of toolboxes tailored specifically for biomedical applications equips practitioners with the tools needed to address diverse challenges, from processing intricate medical images to simulating physiological processes. Moreover, Matlab's user-friendly interface and extensive documentation streamline the development process, enabling researchers and students alike to swiftly implement complex algorithms and analyze vast datasets with ease.
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The purpose of this blog post is to extend assistance with Matlab Assignment commonly encountered in biomedical engineering curricula. By providing comprehensive solutions and insightful explanations, this blog aims to bridge the gap between theoretical concepts and practical implementation, empowering students to grasp key principles while honing their Matlab proficiency. Whether it's elucidating the intricacies of image segmentation algorithms for medical image analysis or simulating the dynamics of physiological systems using mathematical models, this blog endeavors to offer clear, concise, and practical solutions to common biomedical engineering assignments.
Within the realm of biomedical engineering, Matlab serves as a catalyst for innovation, facilitating the development of cutting-edge medical technologies and enhancing our understanding of complex biological phenomena. Its versatility extends to applications such as medical imaging, where Matlab algorithms are utilized for tasks ranging from noise reduction and feature extraction to the reconstruction of three-dimensional anatomical models from medical scans. In the domain of signal processing, Matlab's robust signal analysis toolboxes empower researchers to unravel meaningful insights from biomedical signals such as electrocardiograms (ECGs), electroencephalograms (EEGs), and electromyograms (EMGs), aiding in the diagnosis and monitoring of various medical conditions.
Matlab plays a pivotal role in the modeling and simulation of physiological systems, allowing biomedical engineers to construct computational models that mimic the behavior of biological processes with remarkable fidelity. From simulating the dynamics of cardiac electrophysiology to modeling the spread of infectious diseases within populations, Matlab facilitates the exploration and understanding of complex biomedical phenomena, paving the way for innovative solutions to real-world challenges in healthcare and biotechnology.
In summary, Matlab stands as an indispensable tool in the arsenal of biomedical engineers, empowering them to tackle a diverse array of challenges with precision and efficiency. Through this blog post, we aim to provide invaluable assistance with Matlab assignments commonly encountered in biomedical engineering curricula, equipping students with the knowledge and skills needed to excel in this dynamic and impactful field.
Image Processing in Biomedical Engineering
Matlab, renowned for its versatility and robustness, plays a pivotal role in image processing tasks within the realm of biomedical engineering. Through its comprehensive suite of functions and toolboxes tailored for image analysis, Matlab empowers researchers and engineers to manipulate, analyze, and extract valuable insights from biomedical images with unparalleled precision and efficiency.
In the domain of biomedical engineering, image processing serves as a cornerstone for various applications, ranging from diagnostic medical imaging to experimental analysis in research settings. For instance, in medical diagnostics, Matlab facilitates the enhancement and interpretation of medical images acquired through modalities like MRI, CT scans, and X-rays, enabling clinicians to accurately identify and diagnose abnormalities or diseases. Moreover, in biomedical research, Matlab aids in the analysis of microscopic images obtained from experiments, such as cell imaging and histopathology, fostering advancements in areas like drug discovery and tissue engineering.
Assignments related to image processing in biomedical engineering often encompass a spectrum of tasks aimed at extracting meaningful information from images to address specific research questions or clinical needs. These assignments may involve tasks such as noise reduction, segmentation, and feature extraction, each crucial for different stages of image analysis and interpretation. For instance, students might be tasked with developing algorithms in Matlab to denoise medical images by employing techniques like median filtering or wavelet denoising, thereby enhancing image quality for subsequent analysis.
Segmentation, another fundamental task in image processing, involves partitioning an image into meaningful regions or objects to facilitate further analysis. In the context of biomedical engineering, assignments might entail implementing segmentation algorithms in Matlab to delineate structures of interest within medical images, such as organs, tumors, or anatomical features. This facilitates quantitative analysis and measurements essential for diagnostic purposes or research investigations.
Furthermore, feature extraction plays a pivotal role in extracting relevant information or characteristics from images to enable subsequent analysis or classification tasks. Matlab facilitates the implementation of feature extraction techniques, such as texture analysis or shape descriptors, allowing students to extract discriminative features from biomedical images for tasks like disease classification or image-based phenotyping in research studies.
To illustrate, consider a Matlab code snippet for noise reduction utilizing a median filtering approach:
% Read the noisy medical image
noisy_image = imread('noisy_image.png');
% Apply median filtering for noise reduction
filtered_image = medfilt2(noisy_image, [3 3]);
% Display original and filtered images
subplot(1, 2, 1), imshow(noisy_image), title('Original Image');
subplot(1, 2, 2), imshow(filtered_image), title('Filtered Image');
In this snippet, medfilt2 is a Matlab function used to perform median filtering on the noisy image, effectively reducing noise while preserving image details.
In summary, Matlab serves as an indispensable tool for image processing tasks in biomedical engineering, enabling students to tackle assignments encompassing noise reduction, segmentation, feature extraction, and beyond, thereby fostering advancements in medical diagnostics, research, and beyond.
Signal Processing for Biomedical Signals:
Matlab serves as a powerful tool in biomedical engineering for analyzing various types of physiological signals, including electrocardiogram (ECG), electroencephalogram (EEG), and electromyogram (EMG). These signals are crucial for diagnosing and monitoring the activity of the heart, brain, and muscles, respectively. Matlab's extensive signal processing capabilities enable researchers and engineers to extract valuable information from these signals for medical diagnosis, treatment, and research purposes.
In biomedical engineering, typical assignments involving signal processing often revolve around tasks such as noise reduction, feature extraction, spectral analysis, and signal classification. For instance, students may be tasked with designing filters to remove unwanted noise from ECG signals, identifying specific features like QRS complexes, and classifying abnormal patterns indicative of cardiac arrhythmias. Similarly, in EEG analysis, assignments might focus on detecting event-related potentials (ERPs) associated with cognitive processes or identifying abnormal brainwave patterns characteristic of neurological disorders. In EMG signal processing assignments, students may be required to differentiate between muscle activation patterns during various movements or classify EMG signals to diagnose neuromuscular disorders.
Matlab provides a plethora of functions and toolboxes tailored for signal processing tasks in biomedical engineering. For filtering tasks, students can utilize functions like designfilt to design various types of filters such as low-pass, high-pass, or band-pass filters to remove noise from signals effectively. Spectral analysis, which involves analyzing the frequency content of signals, can be performed using functions like pwelch for estimating power spectral density or fft for computing the discrete Fourier transform. Matlab's Signal Processing Toolbox offers comprehensive tools for feature extraction, including functions for detecting peaks, calculating statistical measures, and extracting time-frequency representations like spectrograms.
Signal classification is another crucial aspect of biomedical signal analysis, where Matlab's machine learning capabilities come into play. Students can implement classification algorithms such as support vector machines (SVM), k-nearest neighbors (KNN), or artificial neural networks (ANN) using functions provided in Matlab's Statistics and Machine Learning Toolbox. These algorithms enable the automatic classification of signals into predefined categories, facilitating the diagnosis of medical conditions based on signal characteristics.
Modeling and Simulation in Biomedical Systems:
Modeling and simulation play a pivotal role in advancing biomedical engineering research by providing a means to understand complex physiological processes, predict system behaviors, and test hypotheses in a controlled environment. In the realm of biomedical engineering, where experimentation on living organisms is often impractical, expensive, or ethically challenging, modeling and simulation offer a valuable alternative for exploring the dynamics of biological systems. These tools allow researchers to replicate and manipulate biological phenomena in silico, facilitating a deeper understanding of disease mechanisms, drug interactions, and medical device efficacy.
Matlab, a powerful computational tool widely used in scientific research, offers a comprehensive suite of functionalities for creating detailed models and conducting simulations of biomedical systems. Its versatility in handling mathematical equations, numerical methods, and data visualization makes it particularly well-suited for tackling the intricacies of biological processes. Matlab's extensive library of built-in functions and toolboxes further enhances its capabilities, providing specialized tools for tasks such as image processing, signal analysis, and machine learning—all essential components in biomedical modeling and simulation.
To illustrate Matlab's prowess in this domain, let's consider a sample assignment involving the modeling and simulation of a physiological process: the dynamics of a neuron firing in response to external stimuli. Using Matlab, students can construct a computational model of a neuron based on biophysical principles, incorporating factors such as membrane capacitance, ion channel conductance, and synaptic input. By simulating the differential equations governing neuronal dynamics, students can observe how changes in parameters like stimulus amplitude or membrane potential affect the firing pattern of the neuron.
Furthermore, Matlab allows for the integration of experimental data into the model, enabling students to validate their simulations against empirical observations. This iterative process of model refinement and validation fosters a deeper understanding of the underlying physiological mechanisms and reinforces concepts learned in the classroom. Additionally, Matlab's interactive interface and customizable plotting tools facilitate the visualization and analysis of simulation results, empowering students to extract meaningful insights from their models.
Data Analysis in Biomedical Research:
In the realm of biomedical research, where vast amounts of data are generated from various sources such as medical imaging, physiological monitoring, and genetic sequencing, Matlab emerges as a powerful tool for deciphering complex datasets. Its versatile functionalities empower researchers to delve into the intricate patterns within these datasets, enabling insights crucial for advancing biomedical knowledge and technologies. In tackling large datasets, Matlab plays a pivotal role in data preprocessing, where it aids in cleaning, formatting, and organizing raw data into a manageable form suitable for analysis. For instance, in medical imaging studies, Matlab facilitates the extraction of relevant features from voluminous image datasets, streamlining subsequent analyses.
Moreover, Matlab's prowess shines in a myriad of data analysis assignments pertinent to biomedical engineering. One common task involves statistical analysis, where researchers aim to discern meaningful trends, correlations, and statistical significance within datasets. For instance, Matlab's statistical toolbox equips researchers with a plethora of functions for conducting hypothesis testing, regression analysis, and multivariate analyses tailored to biomedical datasets. In a hypothetical assignment scenario, researchers might utilize Matlab to analyze the effectiveness of a new drug treatment by statistically comparing patient outcomes between treatment and control groups.
Furthermore, Matlab serves as an indispensable platform for data visualization, offering a diverse array of plotting functions and customizable visualization tools. In biomedical research, effective visualization of data is paramount for conveying findings and insights to stakeholders. Matlab facilitates the creation of insightful visualizations ranging from basic histograms and scatter plots to more sophisticated 3D renderings of biomedical phenomena. For instance, researchers might employ Matlab to visualize the spatial distribution of neural activity captured through EEG recordings, aiding in the identification of brain regions implicated in specific tasks or conditions.
Additionally, Matlab's robust machine learning capabilities empower researchers to develop predictive models and uncover complex patterns within biomedical datasets. For example, in a machine learning assignment, researchers might utilize Matlab to train a model for predicting patient outcomes based on diverse clinical variables, such as demographic information, medical history, and biomarker measurements. Leveraging Matlab's machine learning algorithms and tools, researchers can iteratively refine and optimize their models, ultimately enhancing their predictive accuracy and clinical utility.
Conclusion:
In "Biomedical Engineering Applications: Matlab Solutions for Assignments," we delved into the indispensable role of Matlab in tackling challenges within the realm of biomedical engineering. Through this exploration, several key points emerged, illuminating the versatility and efficacy of Matlab in addressing various facets of biomedical engineering assignments. Firstly, we uncovered the pivotal role of image processing in biomedical engineering, elucidating how Matlab serves as a potent tool for tasks like noise reduction, segmentation, and feature extraction, thereby enhancing the analysis of medical images vital for diagnoses and research. Moreover, we examined the crucial domain of signal processing for biomedical signals, showcasing Matlab's prowess in filtering, spectral analysis, and signal classification, crucial for deciphering intricate physiological signals such as ECG, EEG, and EMG. Furthermore, we delved into the realm of modeling and simulation in biomedical systems, underscoring how Matlab facilitates the creation of accurate models and simulations essential for understanding and predicting complex physiological processes. Lastly, we explored the significance of data analysis in biomedical research, demonstrating how Matlab empowers researchers to analyze vast datasets, visualize data, perform statistical analysis, and even delve into machine learning algorithms, thereby unlocking deeper insights into biological phenomena.
In light of these revelations, readers are encouraged to delve deeper into the realm of Matlab, recognizing its immense potential as a catalyst for success in their biomedical engineering assignments. By harnessing the power of Matlab, students can elevate their understanding and proficiency in critical areas such as image processing, signal analysis, modeling, simulation, and data analysis, thereby honing their skills and augmenting their academic achievements. Whether embarking on a journey to decipher complex biomedical signals or unraveling the intricacies of physiological systems through modeling and simulation, Matlab stands as an invaluable ally, equipping students with the tools necessary to surmount challenges and excel in their academic pursuits.
As we embark on this journey together, we extend an open invitation to our readers to share their feedback and suggestions for future topics related to Matlab in biomedical engineering. Your insights are invaluable in shaping the direction of our discourse, ensuring that we address topics that resonate with your interests and aspirations. Whether you seek clarification on a specific Matlab concept or yearn to explore new horizons within the realm of biomedical engineering, your input is pivotal in enriching our collective understanding and fostering a vibrant community of learners passionate about leveraging Matlab for academic excellence. Join us on this odyssey as we unravel the boundless possibilities that await within the dynamic intersection of Matlab and biomedical engineering.
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- Published: 31 July 2024
Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity
- Justin R. Randall 1 ,
- Luiz C. Vieira 2 ,
- Claus O. Wilke 2 &
- Bryan W. Davies ORCID: orcid.org/0000-0002-2046-0341 1
Nature Biomedical Engineering volume 8 , pages 842–853 ( 2024 ) Cite this article
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- Antibiotics
- Machine learning
Many antimicrobial peptides directly disrupt bacterial membranes yet can also damage mammalian membranes. It is therefore central to their therapeutic use that rules governing the membrane selectivity of antimicrobial peptides be deciphered. However, this is difficult even for short peptides owing to the large combinatorial space of amino acid sequences. Here we describe a method for measuring the loss or maintenance of antimicrobial-peptide activity for thousands of peptide-sequence variants simultaneously, and its application to Protegrin-1, a potent yet toxic antimicrobial peptide, to determine the positional importance and flexibility of residues across its sequence while identifying variants with changes in membrane selectivity. More bacterially selective variants maintained a membrane-bound secondary structure while avoiding aromatic residues and cysteine pairs. A machine-learning model trained with our datasets accurately predicted membrane-specific activities for over 5.7 million Protegrin-1 variants, and identified one variant that showed substantially reduced toxicity and retention of activity in a mouse model of intraperitoneal infection. The high-throughput methodology may help elucidate sequence–structure–function relationships in antimicrobial peptides and inform the design of peptide-based synthetic drugs.
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Identification of potent antimicrobial peptides via a machine-learning pipeline that mines the entire space of peptide sequences
Data availability.
Raw sequencing data from dmSLAY are available from the SRA database under accession number PRJNA1022479 . The raw and analysed datasets generated during the study are available for research purposes from the corresponding author on reasonable request. Source data for the figures are provided with this paper.
Code availability
Coding materials for sequence analysis and machine learning are available on GitHub at https://github.com/facebookresearch/esm#main-models ref. 40 and https://github.com/ziul-bio/DMS_ML_AMP ref. 41 .
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Acknowledgements
We thank the Targeted Therapeutic Drug Discovery and Development Program at the University of Texas for access to circular dichroism training and equipment. The authors disclose support for the research described in this study from the National Institutes of Health (grant numbers AI125337, AI148419 and AI159203), the Welch Foundation (grant number F-2137), the Defense Threat Reduction Agency (grant number ADTRA1-17-C0008) and Tito’s Handmade Vodka.
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Justin R. Randall & Bryan W. Davies
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J.R.R., L.C.V., B.W.D. and C.O.W. conceptualized this work. J.R.R. and L.C.V. were responsible for methodology, investigation and data visualization. B.W.D. and C.O.W. supervised the work and acquired funding. J.R.R. wrote the original draft and L.C.V., B.W.D. and C.O.W. helped with editing.
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Extended data
Extended data fig. 1 protegin-1 dmslay library diversity and sequencing analysis..
a , an alanine scan performed on the native Protegrin-1 (PG-1.0) amino acid sequence showing antibacterial activity (MIC) in µg/ml. Reported MIC is the median of triplicate reactions. b , Chart of the sequence variance found within the Protegrin-1 dmSLAY library. The native Protegrin-1 sequence is shown at the top with mutations observed at each location within the library below. Amino acids are color coded by side chain similarity. Brackets represent where disulfide bonds are present. c , Principal Component Analysis of the overall induced and uninduced triplicate sample variance. d , ROC curve with different MIC cut offs for active and inactivity for log 2 -fold change cut off across a range of log 2 -fold change scores (L2FC).
Source data
Extended data fig. 2 selectivity of serine and histidine containing pg-1 variants..
a , Scatter plot of the log 2 -fold change in MIC versus %Hemolysis for dmSLAY active PG-1 variants from Fig. 3 . Dotted line represents PG-1.0 selectivity score. b , Table showing the biochemical characteristics of serine and histidine containing Protegrin-1 variants from dmSLAY. MIC is the median of triplicate assays and %Hemolysis is the mean of triplicate assays. c , Bar chart showing the selectivity score of serine and histidine containing variants on a log 2 scale. Residue changes are shown below. Brackets show where disulfide bonds are formed in the native structure.
Extended Data Fig. 3 Comparing Protegrin-1 variant activity in mixed cultures.
a-d , Graphs of PG-1 (top left), PG-1.1 (bottom left), PG-1.20 (top right), and PG1-37 (bottom right) percentage of bacterial killing (green) and % hemolysis (purple) with 1 × 10 9 red blood cells (RBC), 1 × 10 6 E. coli W3110 cells (Bacteria) or both at various concentrations shown on a log 2 scale. Each data point is the mean of triplicate reactions and error bars are one standard deviation.
Extended Data Fig. 4 Training of machine learning models and specific attribute mutational profiles.
a , Precision and recall of for predicting PG-1 variants with an MIC > or < 8 µg/ml. b , predicted versus true hemolysis for trained and test data c , or predicted versus true log 10 -selectivity score. All models were trained on 80% of data and validated with 20%. Bottom panels : Mutational profiles of variants from 5.7 million candidates with a predicted MIC ≤ 8 µg/ml ( a ) % hemolysis ≤ 2 ( b ) or log 10 -Selectivity score ≤ 0.5 ( c) .
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Machine-learning-identified Protegin-1 variants.
Source Data for Figs. 1–6 and Extended Data Figs. 1–4
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Randall, J.R., Vieira, L.C., Wilke, C.O. et al. Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity. Nat. Biomed. Eng 8 , 842–853 (2024). https://doi.org/10.1038/s41551-024-01243-1
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Published : 31 July 2024
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DOI : https://doi.org/10.1038/s41551-024-01243-1
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Score A+ in Biomedical Engineering Assignment
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Biomedical Engineering and Nanotechnology
Biomedical engineering and nanotechnology are known to have very close relations and have benefited the technological as well as medical industries together. Together they can transform the most basic form of science into highly advanced techniques, processes, and devices. They have been known to work quite extensively with each other and have been known to benefit almost all areas of engineering together. Nanotechnologists, having even the most basic information on biomedical engineering can lead to life-changing transformations by combining them both. Nanotechnologies have been proven essential for both medicine as well for engineering and this is the reason why it has found its position in biomedical engineering applications. Both nanotechnology and biomedical engineering play a very essential role in the currently emerging technologies which lead to better health care facilities and sustainability. The applications of combined nanotechnology and biomedical engineering are extensively diverse. Biomedical engineering and nanotechnology when combined find their applications in sustainable energy, drug and vaccine delivery, personalized medicine, regenerative medicine, biomedical imaging, and many more. The fields of biomedical engineering and nanotechnology illustrate the importance of the cross-disciplinary branches of the sciences. With the help of these two fields together, the doctors and the researchers are being able to explore the exact study of the diseases and the medicines in a new way.
The scope of biomedical engineering is so everlasting, that future generations cannot be imagined without the presence of biomedical engineering research. When both biology and engineering come together with the scope of research and study increases a thousandfold. Biomedical engineering has been known to lead to a number of innovations and discoveries already and is supposed to be a discipline providing a very wide scope of research. Most of the students are pursuing this uniquely interesting field of biomedical engineering and are enjoying it with all their hearts. Considering the amount of demand for the technologies in the healthcare and medicinal sector, it can be said that the scope of biomedical engineering is extensively vivid and vast.
Some of the biomedical engineering applications have been already described in the above section of this excerpt. Some of the examples of extremely innovative biomedical engineering applications can be minimally invasive surgeries and robotic surgeries. The minimally invasive surgeries include making small incisions in the human body instead of cutting the human body during surgeries, and then inserting tube carrying cameras through the incisions in the body and carrying out surgery through designed surgical instruments. Robotic surgeries involve the use of robots for surgery purposes. Some other biomedical engineering applications include regenerative tissue growth in the medical area and the non-invasive form of medical devices.
Journal of Biomedical Engineering
A journal of biomedical engineering includes all the information on biomedical engineering research that is taking place anywhere in the contemporary world. If you are looking for any kind of information about biomedical engineering then a biomedical engineering journal is something that you need very badly. Different kinds of the journal of biomedical engineering are available these days. The main motive behind these journals is to keep the students, researchers, doctors, or anyone who is interested, up to date with information on biomedical engineering. If you feel even a bit interested in biomedical engineering and you wish to know anything about it, you can refer to a biomedical engineering journal in order to get an overview of biomedical engineering. The journals include all the information on biomedical engineering research and all the new discoveries and innovation in the field.
Certain Specialization of Biomedical Engineering
Biomedical engineering is a vast and extensively used discipline having cross-disciplinary relationships with a lot of disciplines. The scope of biomedical engineering is extremely unending considering the applications of biomedical engineering in various fields. Below mentioned are some of the sub-disciplines that lead to a better and higher level of biomedical engineering research.
- Bio-Instrumentation - It basically consists of concepts of computer sciences, electronics engineering, and the principles of the measurements in order to produce the devices that are used to create further and better diagnosis and treatment of diseases.
- Biomechanics - The science of biomechanics deals with the application of the concepts of mechanical engineering for the purpose of solving problems in the medical field.
- Clinical Engineering - This field of engineering focuses mainly on the applications of the main principles of the medical and technology in order to benefit the health care facilities and clinical environments.
- Bio-Materials - This is the field of biomedical engineering which includes the study and the development of the different materials that are used in biomedical engineering applications. The materials are mainly natural and synthetic.
- Systemic Physiology - This discipline stresses the use of the application of different kinds of engineering tools in order to understand the dynamics as well as the behavior of different kinds of living organisms.
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Lesson Muscles, Oh My!
Grade Level: 6 (5-7)
Time Required: 15 minutes
Lesson Dependency: None
Subject Areas: Biology, Life Science, Science and Technology
NGSS Performance Expectations:
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Curriculum in this Unit Units serve as guides to a particular content or subject area. Nested under units are lessons (in purple) and hands-on activities (in blue). Note that not all lessons and activities will exist under a unit, and instead may exist as "standalone" curriculum.
- Prosthetic Party: Build and Test Replacement Legs
- Sticks and Stones Will Break That Bone!
- The Artificial Bicep
- Measuring Our Muscles
- Clearing a Path to the Heart
- Polluted Air = Polluted Lungs
- Protect That Pill
- Sounds All Around
- Protect Those Eyes
- You're the Expert
- DNA Profiling & CODIS: Who Robbed the Bank?
- Repairing Broken Bones
- Living with Your Liver
Unit | Lesson | Activity |
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Engineering connection, learning objectives, worksheets and attachments, more curriculum like this, pre-req knowledge, introduction/motivation, associated activities, lesson closure, vocabulary/definitions, user comments & tips.
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Engineers must understand how the body works and, in particular, how muscles function in order to assist medical doctors in solving challenges with our muscular system. Biomedical engineers apply their engineering background to design devices to help restore muscle functionality through the use of prosthetics that attach to existing limbs or through the use of special machines to exercise muscles for strengthening and/or survival. Through biomechanics, engineers assess the physical capabilities and limitations of the muscular system, with the overall goal of improvement of health and quality of life.
After this lesson, students should be able to:
- Explain why biomedical engineers are interested in the muscular system.
- Name some devices biomedical engineers have created to aid the muscular system.
- Explain some specific injuries related to the muscular system.
Educational Standards Each TeachEngineering lesson or activity is correlated to one or more K-12 science, technology, engineering or math (STEM) educational standards. All 100,000+ K-12 STEM standards covered in TeachEngineering are collected, maintained and packaged by the Achievement Standards Network (ASN) , a project of D2L (www.achievementstandards.org). In the ASN, standards are hierarchically structured: first by source; e.g. , by state; within source by type; e.g. , science or mathematics; within type by subtype, then by grade, etc .
Ngss: next generation science standards - science.
NGSS Performance Expectation | ||
---|---|---|
MS-LS1-3. Use argument supported by evidence for how the body is a system of interacting subsystems composed of groups of cells. (Grades 6 - 8) Do you agree with this alignment? Thanks for your feedback! | ||
This lesson focuses on the following aspects of NGSS: | ||
Science & Engineering Practices | Disciplinary Core Ideas | Crosscutting Concepts |
Use an oral and written argument supported by evidence to support or refute an explanation or a model for a phenomenon. Alignment agreement: Thanks for your feedback! | In multicellular organisms, the body is a system of multiple interacting subsystems. These subsystems are groups of cells that work together to form tissues and organs that are specialized for particular body functions. Alignment agreement: Thanks for your feedback! | Systems may interact with other systems; they may have sub-systems and be a part of larger complex systems. Alignment agreement: Thanks for your feedback! Scientists and engineers are guided by habits of mind such as intellectual honesty, tolerance of ambiguity, skepticism, and openness to new ideas.Alignment agreement: Thanks for your feedback! |
International Technology and Engineering Educators Association - Technology
View aligned curriculum
Do you agree with this alignment? Thanks for your feedback!
State Standards
Colorado - science.
A basic understanding of the human muscular system.
![Photo shows a woman with a support structured strapped to her left arm and a messenger-type bag hanging across her torso. Photo shows a woman with a support structured strapped to her left arm and a messenger-type bag hanging across her torso.](https://www.teachengineering.org/content/cub_/lessons/cub_images/cub_biomed_lesson02_figure1.jpg)
Engineers play an important role in the medical health world. By understanding the human body, engineers are able to design machines to help doctors and patients heal and repair damaged muscles. These engineers are called biomedical engineers and they work on the entire human body, including the muscular system. They can design machines to help heal torn muscles, and even change non-working muscles into fully-functioning ones. Biomedical engineers have been able to help people — ranging from infants to elderly to professional athletes — with injuries as common as a muscle strain to more serious conditions, such as paralysis. Refer to the associated activity The Artificial Bicep to give students a better understanding of the muscular system and engineering by designing a biomedical device to aid in the recovery of a strained bicep.
Muscle strains occur when you overwork a particular muscle. For example, if you picked up a baseball and threw it as hard as you could many, many times, there is a good chance that you would hurt your arm, specifically its muscles and tendons. For injured muscles, such as a muscle strain, engineers have developed several machines to help the muscle recover quickly. One of these pieces of equipment is an ultrasound device. Basically, an ultrasound device focuses sound waves (which we cannot hear) on the injured muscle providing deep muscle stimulation, which increases blood flow and promotes healing. The end result is a muscle that recovers more quickly than if it was left alone. The faster a muscle recovers, the sooner you can resume playing your sport or performing your regular daily activities.
Biomedical engineers also help develop machines for people who are paralyzed. Paralysis is the loss of the ability to use part or all of the body. Biomedical engineers work on designing devices that can help undo the effects of paralysis. For example, engineers created a robotic brace to help stroke victims with resulting arm paralysis (see Figure 1). This device helps a person use their arm by providing machine-powered assistance. In addition, it doubles as physical therapy because as the machine moves the arm, the injured arm learns to function again. Over time, most stroke victims, in this example, eventually regain full functionality of their arm, which was directly affected by their stroke. Devices such as this one make biomedical engineering an important part of people's health and wellbeing. Refer to the associated activity Measuring Our Muscles for students to investigate other ways in which biomedical engineers provide more insights into muscle performance by designing and developing a model hand dynamometer to collect and analyze data on grip strength and determining how much force muscles can produce.
(optional) Read aloud to students or give as a handout the attached Robotic Brace Reading , a description of the engineering design and prototype testing of a medical device technology (shown in Figure 1) that helps people relearn how to move severely weak or partially paralyzed limbs.
Lesson Background and Concepts for Teachers
Biomedical engineers understand the muscular system and the three different types of muscle groups: skeletal, smooth and cardiac. Skeletal muscles (which we are focusing on in this lesson) connect to tendons and then to bones to provide for movement. Smooth muscles work with the body's organs. Cardiac muscles provide the force to pump the heart.
Biomechanics is a discipline involving the analysis of forces acting on and produced by a living system. Engineers who work in biomechanics are interested in finding out exactly how much force muscles are capable of producing and how the muscles react when outside loads are applied. By examining the effect of forces placed on muscles, bones and joints, engineers can determine the physical capabilities and limitations of the human body. As a result, doctors, physicians, athletes and others have found biomechanical engineers helpful in solving real-life problems related to health, the human body and especially, the muscular system.
Although muscles are necessary for movement, many components work together to provide human motion; these basic parts are collectively known as the musculoskelatal system . The system consists of muscles, tendons, ligaments, bones and cartilage, which are typically found where two or more bones are joined together, at a joint . Each bone usually has at least two pairs of muscles to exert forces on neighboring bones connected at the joint.
![A diagram of a bent elbow shows bones, extensor muscles, flexor muscles, ligaments, tendons and cartilage. A diagram of a bent elbow shows bones, extensor muscles, flexor muscles, ligaments, tendons and cartilage.](https://www.teachengineering.org/content/cub_/lessons/cub_images/cub_biomed_lesson02_image2.jpg)
Our musculoskeletal system is essentially the combination of many simple levers (bones) operated by ropes (muscles) to move the structure about. Muscles produce motion in a similar way to ropes in an engineering system; they can pull, but they cannot push. In studying mechanics, engineers call a pulling force tension and a pushing force compression . Since bones are secured at the joint, when a tension force from a muscle pulls on a bone, a tendency for the bone to rotate about the joint is created. This turning, or rotating effect, produced by such a force is what engineers call a moment , or torque. Because each group of muscles produces tension forces in only a single direction, every bone usually has at least two muscles to achieve motion in multiple directions; one is called a flexor and another called an extensor . For motion in one direction, the flexor contracts to pull and rotate the bone one way, while the extensor is relaxed. For motion in the opposite direction, the extensor contracts to pull and rotate the same bone the other way, while the flexor is relaxed. Nearly every motion of the body is produced by a combination of these two pairs of muscles contracting and relaxing in unison.
Biomedical engineering blends traditional engineering techniques with the biological sciences and medicine to improve the quality of human health and life. Biomedical engineers are increasingly demonstrating that traditional engineering expertise applied to the life sciences is helpful in solving problems in human health. This relatively new area of engineering applies to several diverse disciplines including biology, ergonomics, kinesiology, physiology, medicine, orthopedics and mechanical physics. Professionals in these fields depend upon the assistance of engineers with a strong understanding of biomechanics and the musculoskeletal system. Their passion for improving human health and our quality of life ultimately improves the lives of hundreds of thousands of people who are injured every year.
The attached Robotic Brace Reading provides more information on the engineering design and prototype testing of medical device technology that helps people relearn how to move severely weak or partially paralyzed limbs.
Watch this activity on YouTube
- Measuring Our Muscles - Student teams act as engineers, designing and developing a model hand dynamometer to collect and analyze data on grip strength and determining how much force muscles can produce.
Why is it important to care for our muscles and not overstress them? (Answer: Our muscles are important to being able to move in order to perform our everyday activities. Our muscles may become injured if they are exerted beyond their capabilities. One example is a muscle strain.) How do biomedical engineers help us heal and repair injured muscles? (Answer: Engineers design machines that repair torn muscles, and even change non-working muscles into fully-functioning ones.) Who might biomedical engineers help? (Answer: Anyone, ranging from children to elderly to professional athletes with injuries.) What types of injuries might they help to restore? (Answer: Common injuries such as muscle strains, along more serious injuries such as paralysis.) So, we have learned today that the human body, and in particular the muscular system, can be analyzed by engineers to help solve medical and engineering problems and improve the quality of life for persons with disabilities, either on short-term or long-term basis.
biomechanics: The study of the mechanics of a living body, especially of the forces exerted by muscles and gravity on the skeletal structure. May also include the study of the mechanics of a part or function of a living body, such as of the heart or of locomotion.
biomedical engineer: A person who blends traditional engineering techniques with the biological sciences and medicine to improve the quality of human health and life.
cardiac muscle: An involuntary muscle found in the walls of the heart that pumps the blood through our bodies.
engineer: A person who applies his/her understanding of science and math to creating things for the benefit of humanity and our world.
muscular system: The anatomical system of a species that enables it to move.
paralysis: The loss of the ability to move in part or much of the body.
skeletal muscle: The voluntary muscles attached to our skeleton, which enable our bodies to move.
smooth muscle: Involuntary muscles found in the walls of our body's organs.
Pre-Lesson Assessment
Question/Answer : Ask the students and discuss as a class:
- Are the muscles in our bodies important? Why? (Possible answers: Our muscles enable our bodies to move and operate; to create physical motion.)
- Do engineers have any interest in the human body? (Answer: Yes, engineers want to understand how the body works so they can design and create devices to help fix problems that can occur.)
Post-Introduction Assessment
- Why might biomedical engineers be interested in the human muscular system? (Answer: Because our muscular system can have problems and injuries that require help. Biomedical engineers can help by designing devices to aid in the recovery of our damaged muscles.)
Lesson Summary Assessment
Biomedical Engineering and Muscle Movement : Have students pick a basic motion that involves skeletal muscles. Ask them to write down which muscles are being used, what might happen if one of the muscles was injured, and how biomedical engineers might help fix the muscle. Have each student describe and explain their biomedical situation to the class.
Review : Using what they learned, have students describe how the body is a system of multiple interacting subsystems.
Lesson Extension Activities
Continue the class discussion by posing the following questions for students to think about and then discuss together:
- Why do you think people in some cultures carry loads on their heads? (Discussion points: With this technique, the load is distributed down the back and supported by the skeletal system without producing a force around any joint, which muscles must counteract. This method uses fewer muscles and relies more on the support of the skeletal system; hence, your muscles do not tire as quickly.)
- (Use the classroom door to demonstrate a simple lever) Why is it easier to open the door if I push on the edge of the door far away from the hinge, compared to pushing on the door close to the hinge? (Discussion points: Engineers call this "leverage." Leverage is when less force is needed to produce the same amount of work. Less force is needed if we use a longer lever. That means less muscular force is required if we push at a spot farther away from the hinge.)
Artificial muscle implants are been studied for use by astronauts orbiting in space and persons on Earth with muscle-degeneration diseases. Have students research the effects of muscles in space and discuss how artificial muscle implants might help with this problem.
(For more advanced students) Using the Mechanics of Muscle Motion Handout (which requires the use of basic algebra), have students calculate the maximum amount of weight the average student can lift; W = (ℓF)/d. Assume reasonable values for the variables (for example, d = 0.25 m [9.84 in], ℓ= 0.0325 m [1.28 in], maximum bicep strength: F = 240 N [54.0 lbs]).
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Students learn about the function and components of the human nervous system, which helps them understand the purpose of our brains, spinal cords, nerves and five senses. In addition, how the nervous system is affected during spaceflight is also discussed.
![biomedical engineering assignment help preview of 'Nerve Racking' Lesson](https://www.teachengineering.org/content/images/SquareImages/cub_human_lesson06.jpg)
Students learn all about muscles, including the three different types of muscles in the human body and the effects of microgravity on muscles. They also learn how astronauts must exercise in order to lessen muscle atrophy in space. Students discover what types of equipment engineers design to help t...
![biomedical engineering assignment help preview of 'Move Your Muscles!' Lesson](https://www.teachengineering.org/content/images/SquareImages/cub_human_lesson02.jpg)
Students extend their knowledge of the skeletal system to biomedical engineering design, specifically the concept of artificial limbs and joints. Students relate the skeleton as a structural system, focusing on the leg as structural necessity. They learn about the design considerations involved in t...
![biomedical engineering assignment help preview of 'Engineering Bones' Lesson](https://www.teachengineering.org/content/images/SquareImages/engineering_bones.png)
This lesson covers the topic of human bones and joints. Students learn about the skeleton, the number of and types of bones in the body, and how outer space affects astronauts' bones. Students also learn how to take care of their bones here on Earth to prevent osteoporosis ─ or weakening of the bone...
![biomedical engineering assignment help preview of 'Our Amazing Skeleton' Lesson](https://www.teachengineering.org/content/images/SquareImages/cub_human_lesson03.jpg)
Dictionary.com. Lexico Publishing Group, LLC. Accessed November 20, 2008.
Halber, Deborah. Robotic Brace Aids Stroke Recovery: Worn on the Arm, NeuroRobotic Device is Lightweight, Portable. Published March 21, 2007. TechTalk: Serving the MIT Community, Vol. 51, No. 22 and News Office, Massachusetts Institute of Technology. web.mit.edu/newsoffice/2007/techtalk51-21.pdf Accessed November 18, 2008.
Leveau, Barney F. Williams & Lissner's Biomechanics of Human Motion. Philadelphia, PA: W. B. Saunders Company, 1962.
Myomo, Inc. Boston, MA. (A company that creates NeuroRobotics – a new category of non-invasive medical device technology to help people relearn how to move severely weak or partially paralyzed limbs. Myomo is an acronym for "my own motion.") www.myomo.com Accessed November 18, 2008.
Planning a Career in Biomedical Engineering. Careers, Biomedical Engineering Society (BMES). www.scribd.com/doc/4894511/Planning-a-Career-in-Biomedical-Engineering Accessed November 3, 2010.
Contributors
Supporting program, acknowledgements.
The contents of this digital library curriculum were developed under a grant from the Fund for the Improvement of Postsecondary Education (FIPSE), U.S. Department of Education and National Science Foundation GK-12 grant no. 0338326. However, these contents do not necessarily represent the policies of the Department of Education or National Science Foundation, and you should not assume endorsement by the federal government.
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What is Biomedical Engineering?
Applying the principles and problem-solving techniques of biology to engineering forms the basis of biomedical engineering. This form of engineering is prevalent in many healthcare systems and medical educational institutes. Diagnosis and analysis of healthcare issues to treatment and recovery is mostly based on biomedical engineering. The inventions of implantable medical devices like pacemakers, artificial hips and knee plates, stem cell engineering and the 3D printing of organs has only been made possible because of biomedical engineering. The ideas that help to advance human health and professional health care fall under biomedical engineering. Engineering as a whole is abundantly vast and innovative and so is this field under it.
Biomedical engineering differs from other engineering fields. Be it an advanced prosthetic limb or a breakthrough in major organ transplantation, aspects of chemistry, mathematics, material science, electrical and mechanical engineering are all integrated in human biology. There is a huge scope in this field. Following the Covid-19 pandemic, biomedical engineering has gained a lot of traction. The opportunities are ever growing within the industry and in biological academia for furthering research and establishing safety standards for medical devices.
What is the job outlook for Biomedical Engineering?
The U.S. BUREAU OF LABOUR STATISTICS states that by 2030, the employment of biomedical engineers is expected to grow by 6%. A plethora of career opportunities are available in the $400 billion global medical device industry and the trillion-dollar pharmaceutical industry. for aspiring biomedical engineers. From product development and management to bioinformatics and data science, choosing the right program and specialisation will help you take advantage of the opportunities available. This is often called a “Bright Outlook” occupation. One can make anywhere between $85,000 to $100,000 annually. This can increase with increase in specialisations and experience. They also have to work full time and with other professionals in the same field.
Skills of a good biomedical engineer
Just akin to other engineering fields, becoming a great biomedical engineer requires tremendous skills and hard work. One should have strong research and development, analytical and efficient problem solving skills. Technical expertise will always be crucial to the job, which also includes computer-aided design skills. Interpersonal skills such as attention to detail, ability to work in a multidisciplinary team and under pressure and a strong awareness of health and safety issues are some key skills needed for pursuing biomedical engineering. All biomedical engineers require in-depth engineering knowhow in a particular disciplinary area.
How to study biomedical engineering in Australia?
After further consideration, if you wish to pursue biomedical engineering in Australia, you would need a formal qualification. Biomedical Engineering aspirants must complete an engineering qualification. You should complete a 4 year full time Bachelor of Engineering in Biomedical Engineering from a university. You must complete Year 12 education in one or more subjects such as English, mathematics, physics, and chemistry.
You can experience in the field by working on internships of medical and prosthetic design. The Bachelors of Biomedical Engineering course is accredited by Engineers Australia. RMIT, UNSW and University of Melbourne offer courses in this domain as well. The University of Sydney, Monash University, Flinders University, University of Adelaide and University of Technology, Sydney also offer various degree courses in this field. Specialisations in thermofluids, biocomputation, bionics and bioelectronics and humanitarian engineering are also available to pursue in Australia. The tuition fees of biomedical courses fall between 40,000 AUD to 50,000 AUD. If you are an international student, you will be required to give the IELTS, PTE and TOEFL exams to apply for admissions. Scholarships are provided, given that the required documents are produced.
Disadvantages and Advantages of Biomedical Engineering
Some of the disadvantages to being a biomedical engineer are:
- Work hours- As those working in hospitals or research labs often work on time sensitive projects, work hours can get quite hectic and you may need to work night shifts and on weekends to complete the necessary requirements.
- Risk of injury- As biomedical engineers may often come into contact with hazardous materials and chemicals, they will be prone to injuries. To work as safely as possible, they will have to keep in mind safety procedures and hazard training.
Some advantages of working as a biomedical engineer are:
- Impact and Relevancy – As the population and risk to diseases increases, working to create technology that betters the quality of life for those with disabilities, illnesses and other health conditions brings stays relevant. These life-saving medical devices are the need of the hour and it positively impacts people all over the world.
- Salary and engaging work – Although the salary would depend on the location and specification of your work, the average national salary in Australia for biomedical engineers is $82,084 AUD. Combining your skills and knowledge of chemistry, biology and computer gives you the chance to explore engaging aspects from each field.
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Frequently asked questions, 1 what is biomedical engineering.
To serve the healthcare industry engineering principles and design concepts are applied to the fields of medicine and biology. Basically, Biomedical Engineering is a branch of engineering. This study makes students know about advanced healthcare procedures and improvise diagnosis and therapy processes. Biomedical engineering fills the gap between engineering and medicine. This uses engineering skills to advance development in biomedical instrumentation and administration. Many bioengineers are working closely with doctors and scientists to boost their medicinal services. These people use lasers, microcomputers, and various other engineering components to declare health ailments. Over the years, biomedical engineers have developed new medical equipment and devices which have been used more in hospitals and diagnostic centres. Today, the biomedical engineering field has become the most advanced and researched field. This subject deals with complicated medical processes as well as with computer applications. This is the most plausible and critical subject that is helping humans to stay healthy, physically and mentally. Students who are pursuing biomedical engineering in top universities and colleges find it difficult to write an assignment. In a student's college life, Assignments are the most important aspects which play a specific role in a student's academic growth. So, students usually have a lot of assignments to write on a regular basis. It is a fact that not every student is familiar with doing creative assignments properly. A lot of students either struggle with it or find it boring. Moreover, there are many intricate topics found in this subject. Therefore, this subject makes it daunting for students to complete the assignments and then students seek help with Biomedical Engineering assignments to get the assignment done accurately. The biomedical engineering homework help is essential for students who lack knowledge of biomedical engineering concepts and do not have the required skills to prepare the best quality assignment. Taking the assistance of our experts at StudyHelpMe would help you reap the best grades without undergoing the hard process of researching and writing.
2 What Are The Different Domains Of Biomedical Engineering?
Biomedical engineering is a vast field that covers the areas of medicine and engineering. Each of the following domains plays an important role in biomedical engineering
Bio-Instrumentation: This domain of biomedical engineering uses different principles of measurement such as computer science as well as electronics to design and manufacture biomedical devices that may ease the job of medical practitioners, surgeons, and clinicians. These devices are used to diagnose several diseases.
Biomaterials: This domain is all about the study of natural materials that are used to manufacture medical devices and are used as artificial organs.
Biomechanics: This domain makes the students learn about the mechanics that are involved in manufacturing biomedical devices. Our assignment writers possess deep knowledge and experience to work in this field and writing assignments. We helped thousands of students who pursue this course in different top universities across the world. Our experts only deliver a high-quality solution.
Rehabilitation engineering: several physicals, as well as physiological disabilities, are treated by using engineering and computer science techniques.
System physiology: This field of study helps students to learn and design different types of engineering tools that are required to understand the functioning of different systems right from bacteria to human beings and how these change with the change in environment. Students who find difficulty in writing assignments on this concept can take Biomedical Engineering project help from our experts at StudyHelpMe.
Tissue Engineering: This specialisation area in biomedical engineering deals with the methods to create artificial organs for patients who would like to transplant their deteriorated organs. Our Biomedical Engineering experts who hold Masters in biomedical engineering with specialisation would help you out with your assignments.
Genetic Engineering: Genetic Engineering makes use of biotechnology to modify the genes of organisms. There are cutting-edge tools that are used such as molecular cloning to bring drastic changes to the structure and traits of organism genes.
Tele-health: This field makes the students learn about advanced telecommunication technologies and electronic information. Our Biomedical Engineering assignment writers have vast knowledge and experience in writing assignments in this specialised area of biomedical engineering. We have been helping students in different places across the globe on craft quality assignments that promise the best grades.
Pharmaceutical Engineering: This study makes students learn how to use technology on chemical agents to carry out medical treatments effectively. If you find it complicated to complete this assignment, now you do not need to worry more, as we are here to help with your biomedical engineering assignments at an affordable price.
3 Where do I get Biomedical Engineering Assignment help for cheap?
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- 100% Plagiarism Free Transtutors.com takes on each assignment with a unique thought process. Adopting this approach helps us churn out assignments that are comprehensive in them, yet different from each other. Our distinguished team of writers and SMEs take all calls for Biomedical Engineering Assignment Assistance with complete dedication and focus.
- 24/7 Customer Support When students search for ‘do my Biomedical Engineering Assignment’, our customer team connects with them to understand all needs. And, we become their partners 24*7. When it comes to extending our support to the students for their assignment submissions, this becomes very important that we are always available.
- On Time Delivery Our Biomedical Engineering Assignment Writer is the perfect partner to work on your assignment. He/she is an experienced professional who is an expert academic writer and a subject expert. All of them are accustomed to the university guidelines for making on time submissions and ensure just that.
- Experienced Experts When a student looks for ‘help with Biomedical Engineering Assignment’, our team of experts is always at their beck and call. We have experienced academic writers, subject experts, and research scholars from the field of Biomedical Engineering on board, who have worked on thousands of assignments until now.
Engineering offers an opportunity to apply one’s knowledge on different subjects like Math, Science in a much practical manner. For the students pursuing engineering as a field of career choice it becomes all the more important to effectively understand the significance it holds. This is because the study gives an opportunity to ideate, innovate, design, structure, and maintain what the theory has been defining all along. However, there is an improved opportunity to actually put in more research to enhance the machinery, structures, tools, systems etc. by cumulating the plethora of knowledge. On these lines for all the students who pick Biomedical Engineering as their discipline of choice, they get an opportunity to study and apply different engineering principles to the field of medicine. However, it is evidenced that Engineering students in various Australian universities get caught up with a lot of work apart from attending regular classes, like working on regular assignments, working on part time jobs etc. Thereby Transtutors.com provides Biomedical Engineering Assignment Help to all such students who seek timely and professional help with their assignments. Since, for many years it has been observed that students are reaching out to professionals for help with Biomedical Engineering Assignment; it is required to understand the discipline in greater details. As specified above this concerned branch of engineering deals with improvement of healthcare services by supporting areas like diagnostics or various therapeutic treatments. Essentially Biomedical Engineering is all about a complete package offering designing and problem solving capabilities that come from engineering, with biological sciences. In the day and age of today, this is being done to offer improved and much advanced healthcare services to people across the globe. This essentially speaks of the advent of multi-disciplinary offerings in all sectors, wherein we can actually see the practical use of one discipline in the other for betterment of human life. Delving deep down, the gamut of Biomedical Engineering services comprise of arenas like Bioinformatics, Biomechanics, Biomaterial, Biomedical optics, Tissue Engineering, Neural Engineering, and Pharmaceutical Engineering. The discipline also covers designing, development, and usage of new age Medical devices, focuses on practices of medical imaging, implants, bionics, Clinical engineering, and Rehabilitation engineering. Since, the discipline is a complicated intermesh of various sub domains or related avenues; it is more difficult for the students to put forth comprehensive and conceptually correct assignments. However, the requirement is just that, so as to earn good grades. While, we cannot take away from the efforts that every student puts into his/her studies, there could be other areas of interest that they want to pursue along with. They could be interested in a sport, or may want to pursue a course in music. Apart from this, students do have different life situations and may be involved in taking care of family members, or earning through part time jobs. Such scenarios do take away the required time and effort to churn exemplary assignments every time and so they have us for help. Our team of experts promises the best assignments that are unique and most comprehensive. Of course, an expert’s take is absolutely in line with the university guidelines and the topic requirements. Moreover, the way they project the assignment in the most professionally savvy language does the task and fetches the best grades.
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Why do students seek for Online Assistance with their Biomedical Engineering Assignments?
It is very important to understand that while Australia offers a great educational ecosystem to students from far and across, it becomes difficult to survive without an additional source of income. This is because the fees, boarding and lodging in metropolitan cities turn out to be too expensive for the students to bear. They are eventually required to work on part time basis. Consequently, they do not get enough time at hand to work dedicatedly on their regular assignment and project submissions.
Biomedical Engineering is a new age extension of various engineering domains and their culmination with ever evolving technologies for the advancement of healthcare facilities. Of course the branch is seeing evolution and interdependencies with various other related branches as mentioned above. Wherein, the related studies that work for improvement and enhancement of healthcare services be like Bioinformatics, Biomechanics, Biomaterial, Tissue Engineering etc. And all these domains collectively work together to improve patient support systems, diagnostic procedures, and much more.
To provide Biomedical Engineering Assignment Assistance, experts at Transtutors.com extends help by suggesting important topics for assignments, offering research services, sharing relevant and very comprehensive assignments. Our Biomedical Engineering Assignment Writers are experts in the subject and are aware of the current topics of significance. They are also accustomed to the university guidelines and decide on the framework and approach accordingly.
Students generally search for keywords like ‘do my Biomedical Engineering Assignment’ and reach out to us for help because we are the industry leaders. From there on it becomes our responsibility to provide them all kinds of assistance, with the assignment, project or research assistance in the subject. Our sole aim is to assist them in a manner that helps them attain the top grades and also clear their exams with flying colors, upon getting better conceptual clarity on all related niches.
Bioinformatics: The field speaks of the new age technological interventions to better manage and understand biological data. It is an interdisciplinary arena comprising concepts from the subjects of science, computers, mathematics, and engineering. This is itself makes it evident that why students look out for ‘help with Biomedical Engineering Assignment’ .
Tissue Engineering: This niche area deals with the study of creation of artificial/man made organs (through biological tissues), for the patients in need of organ transplants.
Genetic Engineering: The domain deals with avenues of DNA technology, study of genetic modification and manipulation, molecular cloning and the likes. Such studies are seeing an enhanced interest for the sake of improvement in crop technology or manufacturing of synthetic human insulin.
On similar lines, Neural Engineering is another related avenue that is focused on the use of different engineering techniques for repairing, replacing and enhancing neural systems.
How does Transtutors.com provide help with Biomedical Engineering Assignments?
Students of Biomedical Engineering in Australia have for long been observed to seek professional help with Biomedical Engineering Assignment. This is a result of other life avenues like devoting time to family, working part time to earn a living and supporting education, involvement in sports, music etc. All these do not leave much time and energy in the students to work on the assignments with complete dedication. They are unable to cope with constant pressure of regular classes, examinations, and assignment submissions. However, the latter is much required for achieving good grades and making up for any loss of grades during the examinations.
Subject experts and academic writers at Transtutors lend that much required helping hand to students seeking Biomedical Engineering Assignment assistance. And, they do so by understanding the essential requirements, the topic and theme in general, making suggestions, and brainstorming on the way forward.
This is because the team understands the benefits of keeping the student in loop and including them in decision making for their project or assignment. Such an approach builds the student’s confidence and he/she is more aware of the assignment. Our Biomedical Engineering Assignment writer is an expert in the subject and a professional academic writer. These qualifications allow them an edge to work on these assignments. Be it a project, paper, assignment, or thesis our writers put in their best upon understanding all requirements.
Our assignment writing services extend across different subject domains, from the fresh year to the final year students. Not only does this helps save a lot of time for these students, but allow them some free time to pursue other interests. When student ask us to ‘do my Biomedical Engineering Assignment’, our team extends all support and understand intricate details and take them into complete confidence.
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Obviously all our assignments, project reports, and papers are just put together by experienced ex-professors and academic writers. The group includes qualified subject experts, ex-faculty members, and industry experts. We feel immensely proud of holding on to strict assessment parameters for selection of every single one of our team members. Every one of them experience numerous levels of tests and one on one meetings with our founders, with the goal that we can guarantee that they are qualified to work on Biomedical Engineering Assignment Help. We ensure that each member has a critical thinking approach, which allows them a broad vision and ability to bring uniqueness to their research and eventual compilation of the assignments.
With each Biomedical Engineering Assignment, the team of writers and SMEs coordinate with the researchers to collect useful information. It is this cohesiveness within different teams that allow us to stand where we are today. We understand the essential thought process of the students who reach out to us, understand the evaluator’s instructions, and move on from there.
Moreover, each assignment that is taken up by our writers stand out by way of comprehensive research, relevant pictorial representations, examples, and a relevant conclusion. These aspects might seem simple, yet hold very significant standing to make every assignment complete and impactful. Also, this gives the student an opportunity to revise the topic comprehensively before his exams and score good grades.
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Biomedical Engineering Assignment help
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Recently Asked Biomedical Engineering Questions
- Q 1 : Write a 1500-word response (excluding references) to the question below. Use APA citation. The anterior cingulate cortex (ACC) is found near the front of the brain and wraps around the head of the corpus callosum. Seizures arising from the cingulate gyrus can be difficult to diagnose and treat due to their deep and medial location. To improve the outcome of the epilepsy surgery in cingulate epilepsy surgery, it is important that we understand cingulate cortex and its epilepsy. Describe common clinical seizure semiologies of the cingulate? Explain how this seizure type is classified? Discuss the role of non-invasive investigations in non-lesional cases. Include a discussion on the localisation of ictal EEG Explain why SEEG technique is favourable to explore the cingulate cortex compared to other invasive techniques. Compare and contrast subdural grid and SEEG technique? Describe challenges and pitfalls of diagnosis and treatment of medically refractory cingulate seizures. See Answer
- Q 2 : Part I: Multiple Alignment A. Go to the EBI multiple sequence alignment tool page: (http://www.ebi.ac.uk/Tools/msa/) B. Click the "Launch Clustal Omega" link and at step 1 paste the CLUSTAL query from the Week 4 links page into the sequences in any supported format window. C. At step 2, click on "output format" and change it to Pearson/FASTA. Now click "submit" and wait for your job to finish. D. When your alignment job finishes, take a picture of your output and insert it here. E. Now click on the "Phylogenetic Tree" tab. This shows the tree used to construct the alignment. Take a picture of your tree and insert it here. F. You can create much nicer and more useful outputs using Mview. Click on the "Results Viewer" tab and then "View in MView" button. At Step 2 select input format: automatic. At step 3 on the MView submission page you can customize how your alignment is colored and formatted. Take a picture of your Mview output and insert it here. G. Return to the EBI multiple sequence alignment tool page: (http://www.ebi.ac.uk/Tools/msa) Repeat steps B-D, except click "Launch T-Coffee" for part B. H. Click on the "Phylogenetic Tree" tab. This shows the tree used to construct the T-Coffee alignment. Take a picture of your tree and insert it here. I. Now send your alignment to MView. At step 3 on the MView submission page be sure to use the same settings as for the Clustal Omega alignment. Take a picture of your Mview T- Coffee output and insert it here. J. Return to the EBI multiple sequence alignment tool page: (http://www.ebi.ac.uk/Tools/msa) Repeat steps B-D, except click "Launch MAFFT" for part B./nB. K. Click on the "Phylogenetic Tree" tab. This shows the tree used to construct the MAFFT alignment. Take a picture of your tree and insert it here. L. Now send your alignment to MView At step 3 on the MView submission page be sure to use the same settings as for the Clustal Omega alignment. Take a picture of your Mview MAFFT output and insert it here. M. Do you see any differences between the three alignments in the order in which the sequences are listed? N. Do you see any differences between the three alignments in the consensus? O. Do you see any other differences between the three alignments? P. Which alignment program would be most appropriate according to the table included in this week's lecture?/nQ. What other alignment methods might have been appropriate? R. What settings (if any) may have increased the quality of the alignment for ClustalOmega or MAFFT? Part II: Finding motifs A. Why is it useful to find motifs? B. Why might motifs be missed by global alignment programs? C. Why can motifs tell us about a group of proteins? D. Copy the "Clustal query" sequences, then go to the meme website http://meme- suite.org/tools/meme a. Select "classic mode" b. Under "Input the primary sequences" select "type in sequences" and then paste the CLUSTAL query from the Week 4 links page into the sequences under input primary sequences "10" for Maximum number of motifs to find then click the "start search" button. When your job finishes use the link at the top of the page to see your results. 1. How many motifs did it find? 2. Did each sequence have the same motifs in the same order?/nB. Now copy the sequence for gi|1084385 then analyze it with Motif Scan at prosite: http://myhits.isb-sib.ch/cgi-bin/motif scan (make sure you check all of the databases below the sequence window) 1. How many motifs did it find? 2. How many were significant (i.e. had a blue exclamation point)? 3. Were there any differences between the two sites? C. Now copy the sequence for gi|1084385 then analyze it with interproscan http://www.ebi.ac.uk/Tools/pfa/iprscan/ 1. What homologous families does this protein belong to? 2. What motifs did it identify? Were any not previously identified? See Answer
- Q 3 : 1. Enzymes: Biological Engineering to Support Bioreactors and Biosensors Enzymes in Weapons Production and Weapons Defense - • Enzymes in Weapons in Bioremediation - a report of at least 2 pages in length (1.5 spacing) with citations (pictures and diagrams are welcome and accepted (and improve your grade) but do not contribute to the 2 pages of report). Please include at least three examples with your general topic description. References See Answer
- Q 4 : 2. Read chapters 5 through 10 and chapters 12 through 14 and other sources. To research the predominant bioengineering careers in the past, those which currently comprise the market and what is forecast for the future. What are the major career options, and where is this going in the future? References See Answer
- Q 5 : 3. Use all resources available to find and describe the biomedical engineering code of ethics, and compare it to the Hippocratic Oath. (Minimum length - approx. 1 page) References See Answer
- Q 6 : - *S5: Discuss appropriate and informed career management choices and entrepreneurial issues* - Consider including a section on the practical applications of studying flaviviruses and pseudotyped viruses in terms of career opportunities and entrepreneurship. See Answer
- Q 7 : 1st submission Student needs 2 Jobs and 2 Business (companies names) Based on instructions of previous work topic Poster Title New strategies to produce pseudotyped viruses to study entry of Flaviviruses Synopsis A pseudotyped virus (PV) is a viral particle harbouring the core structure of one virus and the envelope (Env), the viral protein which interacts with the cellular receptor mediating entry, of a heterologous virus: these PV have been largely employed in gene therapy, serology and virus-host interaction studies. The use of PV is particularly important to study viruses classified as hazard group 3 and 4, as they can be handled at a lower containment level (BSL1/2) and do not require enhanced security, such examples are Ebola and other filoviruses, Lassa fever, Coronaviruses. However, those viruses which assemble within the intracellular membrane systems are particularly difficult to pseudotype, as the incorporation of their Env on the surface of a PV is compromised by the endoplasmic reticulum (ER) retention signal present on their Env. These include viruses which have caused or have the potential to cause an outbreak such as flaviviruses, e.g. Zika virus, Dengue virus and Japanese Encephalitis virus (IEV). Please note: The poster title has been set and the title cannot be changed. See Answer
- Q 8 : 2nd submission It should be exactly like this How does this relate to business and entrepreneurship plus career management? Which businesses have seen an opportunity so far? smartCells go Cord blood and adult stem cell storage company based in the UK offering package options for approximately 2000 plus c100 per year storage fee. BlueRock Therapeutics A joint venture between Bayer and Versant Ventures who have both invested a combined $225 million dollars. The company mainly focuses on technologies around cardiovascular, neurological and autoimmune applications currently. What careers and jobs are available in this sector? Bioinformatics Specialist to T Novo Foundatier for Stem and Protein Research (CP Location tom) Public Engagement Officer Location London, United Kingdom Organisation Centre for Stem Cells and Regenerative Medicine (CSCRM) Laboratory Technician Location: Copenhagen, Denmark Organisation: DanStem What is the industry worth? The global stem cell market size was estimated to be at 56.87 billion in 2016. Transparency Market Research estimate that the global market will be worth $270.5 billion by 2025 research for the job and business/nIt's a group presentation my section is employability I will talk about the jobs and business and how it's related to the job.I will be talking about how we apply this knowledge into real world ... And then I will talk about the jobs and the difference between them and I will say why would I go for this or that job... and then I will talk about the business the example of the business... Career Management Chofces b Job 2 Why لاد Job ل Why Add referebces abd if there any photo of the company logo Idea See Answer
- Q 9 : Fundamentals of Scientific Inquiry We have discussed science throughout history this term, paying particular attention to the paradigm shifts that occurred as scientists reorganized their data to fit with a model that had greater explanatory power. Research a paradigm shift within a particular field of science that we have not covered in class. Choose a particular scientific field (medicine, geology, biology, microbiology, genetics, physics, anatomy, ecology, astronomy, neuroscience, engineering, etc.) Choose a time in which this field was undergoing a great change in thinking or methodology. Argue for whether or not this time in history was a true paradigm shift, given what you know of Thomas Kuhn's definition. In order to do this, you should examine the differences and similarities between the previous era in this scientific field and the one that came after, with reference to the models and methods used and discoveries made. See Answer
- Q 10 : Which of the following is a limitation of surface EMG measurements? See Answer
- Q 11 : What trend best matches what you observed for the changes in EMG magnitude as weight is increased? See Answer
- Q 12 : Make a graph of column F in the isometric weights spreadsheet (50 lb column). What part of the typical processing of EMG does the signal in the F column look like? See Answer
- Q 13 : What was the trend of mean amplitude over time in the EMG fatigue spreadsheet? See Answer
- Q 14 : Which of the following are likely reasons that there is not a perfect fit to the trendline observed in the isometric weights spreadsheet? See Answer
- Q 15 : What was the trend of median frequency over time in the EMG fatigue spreadsheet? See Answer
- Q 16 : Why would the amplitude of EMG show an opposite trend to median frequency in the EMG fatigue spreadsheet? See Answer
- Q 17 : Submit your solutions on Gradescope. 1. [Total: 16 pts] The figure below shows a schematic control block diagram of the control of respiration, with the respiratory controller representing the respiratory chemoreflexes, brain respiratory neural centers and the respiratory muscles, and the lungs representing the CO₂ exchange in the lungs. In amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), motor neuron degeneration results in weakness and eventual paralysis of the respiratory muscles. Note that the regulation of ventilation model here is slightly different (more simplified) from the one we discussed in class. V/₁ Respiratory controller Lungs Pacoz a) [2 pts] Suppose that, in a particular ALS patient, the (steady-state) respiratory controller equation (which characterizes the chemoreflex response) is given by the following equation: V₁ = Paco2 - 37 Where V represents the alveolar ventilation (in L/min), and Pacoz is the partial pressure for CO₂ in the arterial blood (in units of mmHg). Draw (as accurately as possible on the provided graph) the line representing the steady-state controller response to Paco2- Note that we are neglecting the effects of O₂ here. Label this line as "(a)". b) [2 pts] Assume that gas exchange in this patient is normal and can be characterized by the following plant equation: Paco2 = 200/V Draw (as accurately as possible on the provided graph) the relationship between Pacoz and V. Label the curve as "(b)"./nVdotA (L/min) 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0.0 40 41 (mm Hg) c) [2 pts] Estimate the steady-state operating values of Pacoz and V₁ in this patient. d) [4 pts] In a normal healthy person, the controller response is given by V₁ = 2(Paco2-37). Draw this controller response on the graph below. Estimate the steady-state operating values of Paco2 and V in the normal subjects. Label the curve as "(d)". 35 36 37 38 39 P aCO2 42 43 44 45 e) [4 pts] A pressure support ventilator can be used to provide assistance to the ALS patient - such a ventilator would produce an increase of x L/min on top of the subject's own natural ventilatory output, independent of the Pacoz level. However, the ventilator has to be triggered by a minimal inspiratory effort by the patient himself. If the patient does not generate any effort, the ventilator does not provide any ventilatory assistance. Draw on the graph below the total controller response (patient+ ventilator) required to restore the steady-state V and Pacoz values to the levels seen in the normal subject. Label the total controller response as "(e)". f) [2 pts] What is the value of x (L/min)? See Answer
- Q 18 : 2. [15 pts] Assume the metabolic hyperbola for CO₂ given by the following equation: 863 - Vcoz V₁ PACO2 Pico2+ where the normal steady-state CO₂ production is 235 mL/min and the inspired CO₂ concentration (or volumetric fraction) is 0. Also, assume a dead-space ventilation rate of 1 L/min. Also, suppose the steady-state ventilatory response to CO₂ is given by the following equation: 32 Vc = Drive external +(1.46 + (Paco2-37) and Vc 20 Pa02-38.6) Note that the above equation is slightly modified from what we derived in class in that a constant term, Drive external is added to the equation. This drive represents an additional source of control that affects ventilatory response e.g., sleep-wake state, alertness, etc. At normal state (resting and awake), let Drive external = 0. a) [5 pts] Use MATLAB to plot the metabolic hyperbola for CO₂ and the ventilatory response to CO₂ under normal condition. Show both graphs on the same figure (see hold function). Label both axes with appropriate units. Also indicate which graph represents the me the metabolic hyperbola for CO₂ and which graph represents the ventilatory response to CO₂ (see legend function). The plot should show the range of ventilation from 0-20 L/min and the range of PACO₂ from 30-60 mmHg (see xlim and ylim functions). Determine the normal steady-state values of ventilation and Pacoz from the plot (e.g., click on the plot where you want to obtain the x-y coordinates). Note: For the metabolic hyperbola for CO₂, please plot V against PACO₂ i.e., you would take the dead-space ventilation into consideration. b) [4 pts] The onset of sleep causes the external drive to breathe to drop by -5 L/min. State which parameter changes and to what value. Show the graphs representing this situation and report the steady-state values of ventilation and Pacoz. c) [4 pts] Follows from b), how would inhalation of a gas mixture containing 3% CO₂ in air (i.e., volumetric fraction of 0.03) during sleep affect the steady-state values of ventilation and Pacoz? State which parameter changes and to what value. Show the graphs representing this situation and report the steady-state values of ventilation and Pacoz. You may assume that the subject is at sea level. d) [2pt] Copy and paste the MATLAB code you used in this question (all parts). You may take a picture of your MATLAB script, but please make sure that the code is clearly readable from the image. See Answer
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Biomedical Engineers Develop New Way to Help Surgeons See Cancer
Aug 14, 2024 | by Catha Mayor
A new method to help surgeons distinguish cancer from healthy tissue in real time is closer to reality thanks to a joint effort by researchers at Dartmouth Engineering and the University of Wisconsin-Madison Dept. of Medical Physics. Their results, published today in the Proceedings of the National Academy of Sciences (PNAS) , demonstrate a way to use pressure to reveal diseased tissue with poor vasculature, characterized by low oxygen levels—a hallmark of many malignant tumors.
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Dartmouth Engineering researcher Arthur Pétusseau Th'23 demos the PRESTO camera. (Photo by Catha Mayor)
"Even in normal tissue, applying pressure reduces blood flow, and therefore tissue oxygen levels," says Arthur Pétusseau Th'23, a Dartmouth Engineering researcher and the study's first author. "It's like when you press a finger into the skin of your hand and then release it—you can see the blood return quickly. But in tumors, that effect is sustained because the blood flow in tumors is much slower. While normal tissue can re-oxygenate in a couple of seconds, a tumor can take up to five minutes. We leverage this difference to create high contrast between malignant and normal tissue."
The most aggressive, fastest-growing tumors tend to have the least efficient blood flow, making them more prone to oxygen deficiency, known as hypoxia. The researchers developed an imaging system capable of measuring tissue oxygen variations when a surgeon applies pressure to tissue. The system utilizes a specialized camera to capture the fluorescent signals emitted by an imaging agent activated by hypoxia.
"While there are many oxygen-measuring devices out there—like the blood oxygen saturation probes you see on smartwatches—what makes our technology unique is that it maps intracellular oxygen distribution and gives real-time feedback to the surgeon," says Pétusseau. "That makes it potentially usable for many different applications, not only for surgery, but also for any case where hypoxia is an indicator of diseased tissue."
The system was named, "Pressure-Enhanced Sensing of Tissue Oxygenation," or "PRESTO." For Pétusseau, the name was serendipitous. "Not being a native English speaker, I didn't know that 'presto' is what magicians say when they reveal something. But that's kind of what this technique is—the signal that appears in the tumor after pressure is applied to the tissue."
The team is just starting a human clinical study of PRESTO working with the Department of Dermatology at Dartmouth Health. "One of the key advantages of this technology is that, because it relies on tissue oxygen content rather than just the distribution of the imaging agent in the tissue, it can be used for any type of tumor in the body," continues Pétusseau. "We think skin is a good first avenue to test our technology in real-case conditions, as the imaging agent used in PRESTO is already a standard part of skin cancer treatment, and because skin cancer is one of the most common cancers in the US."
"This work by our Wisconsin and Dartmouth groups has high value in surgical guidance and is the result of years of effort, especially by lead authors Arthur and Marien Ochoa ," says Brian Pogue , adjunct professor of engineering at Dartmouth, professor of medical physics at University of Wisconsin-Madison, and president and co-founder of DoseOptics —a radiotherapy imaging technology company founded and run by several of Pétusseau's colleagues.
In fact, the PRESTO camera is based on the core of the DoseOptics camera, with modified acquisition timing that enables real-time imaging. The success of PRESTO, along with the entrepreneurial example set by DoseOptics, has inspired Pétusseau to co-found a new company, "Hypoxia Surgical," with Pogue and Petr Brůža , Dartmouth Engineering professor and lead scientist at DoseOptics.
"I think it's amazing how Dartmouth supports entrepreneurship," says Pétusseau. "The tech-transfer office has been incredibly useful, and during my PhD, I participated in the Magnuson Center innovations accelerator . I even received their Stu Trembly Award , which helped generate some of the data in this paper. Bill Ware [Th'94], the CEO of both DoseOptics and Hypoxia Surgical, has extensive experience in the field, and professors Brůža and Pogue, with their considerable expertise in entrepreneurship, have been exceptionally supportive."
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Biomedical Engineering Assignment Help (24/7 Biomedical Engineering Homework Help)
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Be you are pursuing a bachelor’s or master’s degree in biomedical engineering; throughout your academics you would need to keep on submitting assignments on various topics of Biomedical Engineering. All these assignments carry marks and could have a huge impact on your final grade. If you do not have enough time to write the assignment or lack knowledge on the assigned topic or possess not-so-good writing skills you can seek the help of our industry professionals who have sound knowledge and experience in biomedical engineering. Our in-house Biomedical Engineering assignment helpers hold Master’s and PhD’s in biomedical engineering and thus help you to get the best quality assignment which would earn you A+ grades. Our efficient team can complete the assignment with perfection and without compromising on the quality within the promised timeline. In addition, our skilled and talented Biomedical Engineering experts would do thorough research about the topic and start writing the assignment from the scratch by meeting the specific requirements of students.
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Biomedical engineering is a branch of engineering in which engineering principles and design concepts are applied to the fields of medicine and biology to serve the healthcare industry. This study will let students advance healthcare procedures and improvise diagnosis and therapy processes. This field bridges the gap between engineering and medicine. This will use engineering skills to advance development in biomedical instrumentation and administration. Many bioengineers are working closely with doctors and scientists to boost medicinal services. These people use lasers, microcomputers and various other engineering components to diagnose health ailments. The usage of technology in the medical field would let surgeons carry out surgeries with ease. Over years, biomedical engineers have developed new medical equipment and devices which are been used immensely in hospitals and diagnostic centres.
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Popular Student Queries While Solving Biomedical Engineering Homework & Assignments?
1. What are the key concepts covered in Biomedical Engineering assignments related to advanced imaging techniques? Biomedical Engineering assignments delve into the principles and applications of advanced imaging techniques such as MRI, CT scans, and ultrasound. Students explore their technical aspects, ensuring a comprehensive understanding.
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It is hard for students to remember the complicated terms in biomedical engineering and at the same time preparing an assignment on difficult topics makes their situation worse. Researching the topic to writing the researched content in own words by abiding by the guidelines make it even more challenging and this is why college-goes prefer assignment help services. We, all assignment experts have become the first choice of every student who would want to get their biomedical engineering assignment done today. The reasons behind students choosing our Biomedical Engineering homework help are umpteen.
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Frequently Asked Questions
What topics are covered in biomedical engineering assignment help.
Biomedical Engineering assignment help covers diverse topics such as Biomechanics, Biological Signal Processing, Medical Imaging, Bioinformatics, Biological Material Science, Clinical Engineering, Biosensors and Bioinstrumentation, Rehabilitation Engineering, Tissue Engineering, and Medical Robotics. Students can receive assistance in understanding these subjects, completing assignments, and applying engineering principles to healthcare and biological systems.
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Our Online tutoring benefits in understanding Biomedical Engineering's interdisciplinary nature by providing personalized guidance, addressing doubts in real-time, and offering comprehensive explanations. Biomedical Engineering tutors help students navigate diverse topics, ensuring a holistic understanding of biomedical concepts and fostering interdisciplinary knowledge crucial for success in this field.
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