Work from Home and Productivity: Evidence from Personnel and Analytics Data on Information Technology Professionals

Michael Gibbs, Friederike Mengel, and Christoph Siemroth (2023): "Work from Home and Productivity: Evidence from Personnel and Analytics Data on Information Technology Professionals", Journal of Political Economy Microeconomics, 1(1), 7-41.

39 Pages Posted: 7 May 2021 Last revised: 10 Sep 2023

Michael Gibbs

University of Chicago Booth School of Business; Institute for the Study of Labor (IZA)

Friederike Mengel

University of Essex

Christoph Siemroth

University of Essex - Department of Economics

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Work from Home & Productivity: Evidence from Personnel & Analytics Data on it Professionals

Date Written: March 11, 2022

We study employee productivity (output per hour worked) before and during the working from home [WFH] period of the Covid-19 pandemic, using personnel and analytics data from over 10,000 skilled professionals at a large Asian IT services company. Hours worked increased, including a rise of 18% outside normal business hours. Average output declined slightly and employee productivity fell 8-19%. We then analyze determinants of changes in productivity. An important source is higher communication costs. Time spent on coordination activities and meetings increased, while uninterrupted work hours shrank considerably. Employees networked with fewer individuals and business units, both inside and outside the firm. They received less coaching and 1:1 meetings with supervisors. The findings suggest key issues for firms to address in implementing WFH policies.

Keywords: Collaboration, Coordination, Productivity, Remote Working, Telecommuting, Working From Home, Work Hours, Work Time

JEL Classification: D2, M5

Suggested Citation: Suggested Citation

University of Chicago Booth School of Business ( email )

5807 S. Woodlawn Avenue Chicago, IL 60637 United States

Institute for the Study of Labor (IZA)

P.O. Box 7240 Bonn, D-53072 Germany

Friederike Mengel (Contact Author)

University of essex ( email ).

Wivenhoe Park Colchester, CO4 3SQ United Kingdom

University of Essex - Department of Economics ( email )

Wivenhoe Park Colchester CO4 3SQ United Kingdom

HOME PAGE: http://sites.google.com/site/csiemroth/

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Open Access

Peer-reviewed

Research Article

Researchers working from home: Benefits and challenges

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Software, Validation, Writing – original draft, Writing – review & editing

* E-mail: [email protected]

Affiliation Institute of Psychology, ELTE Eotvos Lorand University, Budapest, Hungary

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Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Institute of Psychology, ELTE Eotvos Lorand University, Budapest, Hungary, Doctoral School of Psychology, ELTE Eotvos Lorand University, Budapest, Hungary

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation Department of Sociology, Utrecht University, Utrecht, The Netherlands

Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  • Balazs Aczel, 
  • Marton Kovacs, 
  • Tanja van der Lippe, 
  • Barnabas Szaszi

PLOS

  • Published: March 25, 2021
  • https://doi.org/10.1371/journal.pone.0249127
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  • Reader Comments

Table 1

The flexibility allowed by the mobilization of technology disintegrated the traditional work-life boundary for most professionals. Whether working from home is the key or impediment to academics’ efficiency and work-life balance became a daunting question for both scientists and their employers. The recent pandemic brought into focus the merits and challenges of working from home on a level of personal experience. Using a convenient sampling, we surveyed 704 academics while working from home and found that the pandemic lockdown decreased the work efficiency for almost half of the researchers but around a quarter of them were more efficient during this time compared to the time before. Based on the gathered personal experience, 70% of the researchers think that in the future they would be similarly or more efficient than before if they could spend more of their work-time at home. They indicated that in the office they are better at sharing thoughts with colleagues, keeping in touch with their team, and collecting data, whereas at home they are better at working on their manuscript, reading the literature, and analyzing their data. Taking well-being also into account, 66% of them would find it ideal to work more from home in the future than they did before the lockdown. These results draw attention to how working from home is becoming a major element of researchers’ life and that we have to learn more about its influencer factors and coping tactics in order to optimize its arrangements.

Citation: Aczel B, Kovacs M, van der Lippe T, Szaszi B (2021) Researchers working from home: Benefits and challenges. PLoS ONE 16(3): e0249127. https://doi.org/10.1371/journal.pone.0249127

Editor: Johnson Chun-Sing Cheung, The University of Hong Kong, HONG KONG

Received: September 24, 2020; Accepted: March 11, 2021; Published: March 25, 2021

Copyright: © 2021 Aczel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Data Availability: All research materials, the collected raw and processed anonymous data, just as well the code for data management and statistical analyses are publicly shared on the OSF page of the project: OSF: https://osf.io/v97fy/ .

Funding: TVL's contribution is part of the research program Sustainable Cooperation – Roadmaps to Resilient Societies (SCOOP). She is grateful to the Netherlands Organization for Scientific Research (NWO) and the Dutch Ministry of Education, Culture and Science (OCW) for their support in the context of its 2017 Gravitation Program (grant number 024.003.025).

Competing interests: The authors have declared that no competing interests exist.

Introduction

Fleeing from the Great Plague that reached Cambridge in 1665, Newton retreated to his countryside home where he continued working for the next year and a half. During this time, he developed his theories on calculus, optics, and the law of gravitation—fundamentally changing the path of science for centuries. Newton himself described this period as the most productive time of his life [ 1 ]. Is working from home indeed the key to efficiency for scientists also in modern times? A solution for working without disturbance by colleagues and being able to manage a work-life balance? What personal and professional factors influence the relation between productivity and working from home? These are the main questions that the present paper aims to tackle. The Covid-19 pandemic provides a unique opportunity to analyze the implications of working from home in great detail.

Working away from the traditional office is increasingly an option in today’s world. The phenomenon has been studied under numerous, partially overlapping terms, such as telecommuting, telework, virtual office, remote work, location independent working, home office. In this paper, we will use ‘working from home’ (WFH), a term that typically covers working from any location other than the dedicated area provided by the employer.

The practice of WFH and its effect on job efficiency and well-being are reasonably well explored outside of academia [ 2 , 3 ]. Internet access and the increase of personal IT infrastructure made WFH a growing trend throughout the last decades [ 4 ]. In 2015, over 12% of EU workers [ 5 ] and near one-quarter of US employees [ 6 ] worked at least partly from home. A recent survey conducted among 27,500 millennials and Gen Z-s indicated that their majority would like to work remotely more frequently [ 7 ]. The literature suggests that people working from home need flexibility for different reasons. Home-working is a typical solution for those who need to look after dependent children [ 8 ] but many employees just seek a better work-life balance [ 7 ] and the comfort of an alternative work environment [ 9 ].

Non-academic areas report work-efficiency benefits for WFH but they also show some downsides of this arrangement. A good example is the broad-scale experiment in which call center employees were randomly assigned to work from home or in the office for nine months [ 10 ]. A 13% work performance increase was found in the working from home group. These workers also reported improved work satisfaction. Still, after the experiment, 50% of them preferred to go back to the office mainly because of feeling isolated at home.

Home-working has several straightforward positive aspects, such as not having to commute, easier management of household responsibilities [ 11 ] and family demands [ 12 ], along with increased autonomy over time use [ 13 , 14 ], and fewer interruptions [ 15 , 16 ]. Personal comfort is often listed as an advantage of the home environment [e.g., 15 ], though setting up a home office comes with physical and infrastructural demands [ 17 ]. People working from home consistently report greater job motivation and satisfaction [ 4 , 11 , 18 , 19 ] which is probably due to the greater work-related control and work-life flexibility [ 20 ]. A longitudinal nationally representative sample of 30,000 households in the UK revealed that homeworking is positively related with leisure time satisfaction [ 21 ], suggesting that people working from home can allocate more time for leisure activities.

Often-mentioned negative aspects of WFH include being disconnected from co-workers, experiencing isolation due to the physical and social distance to team members [ 22 , 23 ]. Also, home-working employees reported more difficulties with switching off and they worked beyond their formal working hours [ 4 ]. Working from home is especially difficult for those with small children [ 24 ], but intrusion from other family members, neighbours, and friends were also found to be major challenges of WFH [e.g., 17 ]. Moreover, being away from the office may also create a lack of visibility and increases teleworkers’ fear that being out of sight limits opportunities for promotion, rewards, and positive performance reviews [ 25 ].

Importantly, increased freedom imposes higher demands on workers to control not just the environment, but themselves too. WFH comes with the need to develop work-life boundary control tactics [ 26 ] and to be skilled at self-discipline, self-motivation, and good time management [ 27 ]. Increased flexibility can easily lead to multitasking and work-family role blurring [ 28 ]. Table 1 provides non-comprehensive lists of mostly positive and mostly negative consequences of WFH, based on the literature reviewed here.

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https://doi.org/10.1371/journal.pone.0249127.t001

Compared to the private sector, our knowledge is scarce about how academics experience working from home. Researchers in higher education institutes work in very similar arrangements. Typically, they are expected to personally attend their workplace, if not for teaching or supervision, then for meetings or to confer with colleagues. In the remaining worktime, they work in their lab or, if allowed, they may choose to do some of their tasks remotely. Along with the benefits on productivity when working from home, academics have already experienced some of its drawbacks at the start of the popularity of personal computers. As Snizek observed in the ‘80s, “(f)aculty who work long hours at home using their microcomputers indicate feelings of isolation and often lament the loss of collegial feedback and reinforcement” [page 622, 29 ].

Until now, the academics whose WFH experience had been given attention were mostly those participating in online distance education [e.g., 30 , 31 ]. They experienced increased autonomy, flexibility in workday schedule, the elimination of unwanted distractions [ 32 ], along with high levels of work productivity and satisfaction [ 33 ], but they also observed inadequate communication and the lack of opportunities for skill development [ 34 ]. The Covid-19 pandemic provided an opportunity to study the WFH experience of a greater spectrum of academics, since at one point most of them had to do all their work from home.

We have only fragmented knowledge about the moderators of WFH success. We know that control over time is limited by the domestic tasks one has while working from home. The view that women’s work is more influenced by family obligations than men’s is consistently shown in the literature [e.g., 35 – 37 ]. Sullivan and Lewis [ 38 ] argued that women who work from home are able to fulfil their domestic role better and manage their family duties more to their satisfaction, but that comes at the expense of higher perceived work–family conflict [see also 39 ]. Not surprisingly, during the COVID-19 pandemic, female scientists suffered a greater disruption than men in their academic productivity and time spent on research, most likely due to demands of childcare [ 40 , 41 ].

In summary, until recently, the effect of WFH on academics’ life and productivity received limited attention. However, during the recent pandemic lockdown, scientists, on an unprecedented scale, had to find solutions to continue their research from home. The situation unavoidably brought into focus the merits and challenges of WFH on a level of personal experience. Institutions were compelled to support WFH arrangements by adequate regulations, services, and infrastructure. Some researchers and institutions might have found benefits in the new arrangements and may wish to continue WFH in some form; for others WFH brought disproportionately larger challenges. The present study aims to facilitate the systematic exploration and support of researchers’ efficiency and work-life balance when working from home.

Materials and methods

Our study procedure and analysis plan were preregistered at https://osf.io/jg5bz (all deviations from the plan are listed in S1 File ). The survey included questions on research work efficiency, work-life balance, demographics, professional and personal background information. The study protocol has been approved by the Institutional Review Board from Eotvos Lorand University, Hungary (approval number: 2020/131). The Transparency Report of the study, the complete text of the questionnaire items and the instructions are shared at our OSF repository: https://osf.io/v97fy/ .

As the objective of this study was to gain insight about researchers’ experience of WFH, we aimed to increase the size and diversity of our sample rather than ascertaining the representativeness of our sample. Therefore, we distributed our online survey link among researchers in professional newsletters, university mailing lists, on social media, and by sending group-emails to authors (additional details about sampling are in S1 File ). As a result of the nature of our sampling strategy, it is not known how many researchers have seen our participation request. Additionally, we did not collect the country of residence of the respondents. Responses analyzed in this study were collected between 2020-04-24 and 2020-07-13. Overall, 858 individuals started the survey and 154 were excluded because they did not continue the survey beyond the first question. As a result, 704 respondents were included in the analysis.

We sent the questionnaire individually to each of the respondents through the Qualtrics Mailer service. Written informed consent and access to the preregistration of the research was provided to every respondent before starting the survey. Then, respondents who agreed to participate in the study could fill out the questionnaire. To encourage participation, we offered that upon completion they can enter a lottery to win a 100 USD voucher.

This is a general description of the survey items. The full survey with the display logic and exact phrasing of the items is transported from Qualtrics and uploaded to the projects’ OSF page: https://osf.io/8ze2g/ .

Efficiency of research work.

The respondents were asked to compare the efficiency of their research work during the lockdown to their work before the lockdown. They were also asked to use their present and previous experience to indicate whether working more from home in the future would change the efficiency of their research work compared to the time before the lockdown. For both questions, they could choose among three options: “less efficient”; “more efficient”, and “similarly efficient”.

Comparing working from home to working in the office.

Participants were asked to compare working from home to working from the office. For this question they could indicate their preference on a 7-point dimension (1: At home; 7: In the office), along 15 efficiency or well-being related aspects of research work (e.g., working on the manuscript, maintaining work-life balance). These aspects were collected in a pilot study conducted with 55 researchers who were asked to indicate in free text responses the areas in which their work benefits/suffers when working from home. More details of the pilot study are provided in S1 File .

Actual and ideal time spent working from home.

To study the actual and ideal time spent working from home, researcher were asked to indicate on a 0–100% scale (1) what percentage of their work time they spent working from home before the pandemic and (2) how much would be ideal for them working from home in the future concerning both research efficiency and work-life balance.

Feasibility of working more from home.

With simple Yes/No options, we asked the respondents to indicate whether they think that working more from home would be feasible considering all their other duties (education, administration, etc.) and the given circumstances at home (infrastructure, level of disturbance).

Background information.

Background questions were asked by providing preset lists concerning their academic position (e.g., full professor), area of research (e.g., social sciences), type of workplace (e.g., purely research institute), gender, age group, living situation (e.g., single-parent with non-adult child(ren)), and the age and the number of their children.

The respondents were also asked to select one of the offered options to indicate: whether or not they worked more from home during the coronavirus lockdown than before; whether it is possible for them to collect data remotely; whether they have education duties at work; if their research requires intensive team-work; whether their home office is fully equipped; whether their partner was also working from home during the pandemic; how far their office is from home; whether they had to do home-schooling during the pandemic; whether there was someone else looking after their child(ren) during their work from home in lockdown. When the question did not apply to them, they could select the ‘NA’ option as well.

Data preprocessing and analyses

All the data preprocessing and analyses were conducted in R [ 42 ], with the use of the tidyverse packages [ 43 ]. Before the analysis of the survey responses, we read all the free-text comments to ascertain that they do not contain personal information and they are in line with the respondent’s answers. We found that for 5 items the respondents’ comments contradicted their survey choices (e.g., whether they have children), therefore, we excluded the responses of the corresponding items from further analyses (see S1 File ). Following the preregistration, we only conducted descriptive statistics of the survey results.

Background information

The summary of the key demographic information of the 704 complete responses is presented in Table 2 . A full summary of all the collected background information of the respondents are available in S1 File .

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https://doi.org/10.1371/journal.pone.0249127.t002

Efficiency of research work

The results showed that 94% (n = 662) of the surveyed researchers worked more from home during the COVID-19 lockdown compared to the time before. Of these researchers, 47% found that due to working more from home their research became, in general, less efficient, 23% found it more efficient, and 30% found no difference compared to working before the lockdown. Within this database, we also explored the effect of the lockdown on the efficiency of people living with children (n = 290). Here, we found that 58% of them experienced that due to working more from home their research became, in general, less efficient, 20% found it more efficient, and 22% found no difference compared to working before the lockdown. Of those researchers who live with children, we found that 71% of the 21 single parents and 57% of the 269 partnered parents found working less efficient when working from home compared to the time before the lockdown.

When asking about how working more from home would affect the efficiency of their research after the lockdown, of those who have not already been working from home full time (n = 684), 29% assumed that it could make their research, in general, less efficient, 29% said that it would be more efficient, and 41% assumed no difference compared to the time before the lockdown ( Fig 1 ).

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https://doi.org/10.1371/journal.pone.0249127.g001

Focusing on the efficiency of the subgroup of people who live with children (n = 295), we found that for 32% their research work would be less efficient, for 30% it would be no different, and for 38% it would be more efficient to work from home after the lockdown, compared to the time before the lockdown.

Comparing working from home to working in the office

When comparing working from home to working in the office in general, people found that they can better achieve certain aspects of the research in one place than the other. They indicated that in the office they are better at sharing thoughts with colleagues, keeping in touch with their team, and collecting data, whereas at home they are better at working on their manuscript, reading the literature, and analyzing their data ( Fig 2 ).

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The bars represent response averages of the given aspects.

https://doi.org/10.1371/journal.pone.0249127.g002

Actual and ideal time spent working from home

We also asked the researchers how much of their work time they spent working from home in the past, and how much it would be ideal for them to work from home in the future concerning both research efficiency and well-being. Fig 3 shows the distribution of percentages of time working from home in the past and in an ideal future. Comparing these values for each researcher, we found that 66% of them want to work more from home in the future than they did before the lockdown, whereas 16% of them want to work less from home, and 18% of them want to spend the same percentage of their work time at home in the future as before. (These latter calculations were not preregistered).

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https://doi.org/10.1371/journal.pone.0249127.g003

Feasibility of working more from home

Taken all their other duties (education, administration, etc.) and provided circumstances at home (infrastructure, level of disturbance), of researchers who would like to work more from home in the future (n = 461), 86% think that it would be possible to do so. Even among those who have teaching duties at work (n = 376), 84% think that more working from home would be ideal and possible.

Researchers’ work and life have radically changed in recent times. The flexibility allowed by the mobilization of technology and the continuous access to the internet disintegrated the traditional work-life boundary. Where, when, and how we work depends more and more on our own arrangements. The recent pandemic only highlighted an already existing task: researchers’ worklife has to be redefined. The key challenge in a new work-life model is to find strategies to balance the demands of work and personal life. As a first step, the present paper explored how working from home affects researchers’ efficiency and well-being.

Our results showed that while the pandemic-related lockdown decreased the work efficiency for almost half of the researchers (47%), around a quarter (23%) of them experienced that they were more efficient during this time compared to the time before. Based on personal experience, 70% of the researchers think that after the lockdown they would be similarly (41%) or more efficient (29%) than before if they could spend more of their work-time at home. The remaining 30% thought that after the lockdown their work efficiency would decrease if they worked from home, which is noticeably lower than the 47% who claimed the same for the lockdown period. From these values we speculate that some of the obstacles of their work efficiency were specific to the pandemic lockdown. Such obstacles could have been the need to learn new methods to teach online [ 44 ] or the trouble adapting to the new lifestyle [ 45 ]. Furthermore, we found that working from the office and working from home support different aspects of research. Not surprisingly, activities that involve colleagues or team members are better bound to the office, but tasks that need focused attention, such as working on the manuscript or analyzing the data are better achieved from home.

A central motivation of our study was to explore what proportion of their worktime researchers would find ideal to work from home, concerning both research efficiency and work-life balance. Two thirds of the researchers indicated that it would be better to work more from home in the future. It seemed that sharing work somewhat equally between the two venues is the most preferred arrangement. A great majority (86%) of those who would like to work more from home in the future, think that it would be possible to do so. As a conclusion, both the work and non-work life of researchers would take benefits should more WFH be allowed and neither workplace duties, nor their domestic circumstances are limits of such a change. That researchers have a preference to work more from home, might be due to the fact that they are more and more pressured by their work. Finishing manuscripts, and reading literature is easier to find time for when working from home.

A main message of the results of our present survey is that although almost half of the respondents reported reduced work efficiency during the lockdown, the majority of them would prefer the current remote work setting to some extent in the future. It is important to stress, however, that working from home is not equally advantageous for researchers. Several external and personal factors must play a role in researchers’ work efficiency and work-life balance. In this analysis, we concentrated only on family status, but further dedicated studies will be required to gain a deeper understanding of the complex interaction of professional, institutional, personal, and domestic factors in this matter. While our study could only initiate the exploration of academics’ WFH benefits and challenges, we can already discuss a few relevant aspects regarding the work-life interface.

Our data show that researchers who live with dependent children can exploit the advantages of working from home less than those who do not have childcare duties, irrespective of the pandemic lockdown. Looking after children is clearly a main source of people’s task overload and, as a result, work-family conflict [ 46 , 47 ]. As an implication, employers should pay special respect to employees’ childcare situations when defining work arrangements. It should be clear, however, that other caring responsibilities should also be respected such as looking after elderly or disabled relatives [ 48 ]. Furthermore, to avoid equating non-work life with family-life, a broader diversity of life circumstances, such as those who live alone, should be taken into consideration [ 49 ].

It seems likely that after the pandemic significantly more work will be supplied from home [ 50 ]. The more of the researchers’ work will be done from home in the future, the greater the challenge will grow to integrate their work and non-work life. The extensive research on work-life conflict, should help us examine the issue and to develop coping strategies applicable for academics’ life. The Boundary Theory [ 26 , 51 , 52 ] proved to be a useful framework to understand the work-home interface. According to this theory, individuals utilize different tactics to create and maintain an ideal level of work-home segmentation. These boundaries often serve as “mental fences” to simplify the environment into domains, such as work or home, to help us attend our roles, such as being an employee or a parent. These boundaries are more or less permeable, depending on how much the individual attending one role can be influenced by another role. Individuals differ in the degree to which they prefer and are able to segment their roles, but each boundary crossing requires a cognitive “leap” between these categories [ 53 ]. The source of conflict is the demands of the different roles and responsibilities competing for one’s physical and mental resources. Working from home can easily blur the boundary between work and non-work domains. The conflict caused by the intrusion of the home world to one’s work time, just as well the intrusion of work tasks to one’s personal life are definite sources of weakened ability to concentrate on one’s tasks [ 54 ], exhaustion [ 55 ], and negative job satisfaction [ 56 ].

What can researchers do to mitigate this challenge? Various tactics have been identified for controlling one’s borders between work and non-work. One can separate the two domains by temporal, physical, behavioral, and communicative segmentation [ 26 ]. Professionals often have preferences and self-developed tactics for boundary management. People who prefer tighter boundary management apply strong segmentation between work and home [ 57 , 58 ]. For instance, they don’t do domestic tasks in worktime (temporal segmentation), close their door when working from home (physical segmentation), don’t read work emails at weekends (behavioral segmentation), or negotiate strict boundary rules with family members (communicative segmentation). People on the other on one side of the segmentation-integration continuum, might not mind, or cannot avoid, ad-hoc boundary-crossings and integrate the two domains by letting private space and time be mixed with their work.

Researchers, just like other workers, need to develop new arrangements and skills to cope with the disintegration of the traditional work-life boundaries. To know how research and education institutes could best support this change would require a comprehensive exploration of the factors in researchers’ WFH life. There is probably no one-size-fits-all approach to promote employees’ efficiency and well-being. Life circumstances often limit how much control people can have over their work-life boundaries when working from home [ 59 ]. Our results strongly indicate that some can boost work efficiency and wellbeing when working from home, others need external solutions, such as the office, to provide boundaries between their life domains. Until we gain comprehensive insight about the topic, individuals are probably the best judges of their own situation and of what arrangements may be beneficial for them in different times [ 60 ]. The more autonomy the employers provide to researchers in distributing their work between the office and home (while not lowering their expectations), the more they let them optimize this arrangement to their circumstances.

Our study has several limitations: to investigate how factors such as research domain, seniority, or geographic location contribute to WFH efficiency and well-being would have needed a much greater sample. Moreover, the country of residence of the respondents was not collected in our survey and this factor could potentially alter the perception of WFH due to differing social and infrastructural factors. Whereas the world-wide lockdown has provided a general experience to WFH to academics, the special circumstances just as well biased their judgment of the arrangement. With this exploratory research, we could only scratch the surface of the topic, the reader can probably generate a number of testable hypotheses that would be relevant to the topic but we could not analyze in this exploration.

Newton working in lockdown became the idealized image of the home-working scientist. Unquestionably, he was a genius, but his success probably needed a fortunate work-life boundary. Should he had noisy neighbours, or taunting domestic duties, he might have achieved much less while working from home. With this paper, we aim to draw attention to how WFH is becoming a major element of researchers’ life and that we have to be prepared for this change. We hope that personal experience or the topic’s relevance to the future of science will invite researchers to continue this work.

Supporting information

https://doi.org/10.1371/journal.pone.0249127.s001

Acknowledgments

We would like to thank Szonja Horvath, Matyas Sarudi, and Zsuzsa Szekely for their help with reviewing the free text responses.

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Scientific breakthroughs: 2024 emerging trends to watch

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December 28, 2023

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Across disciplines and industries, scientific discoveries happen every day, so how can you stay ahead of emerging trends in a thriving landscape? At CAS, we have a unique view of recent scientific breakthroughs, the historical discoveries they were built upon, and the expertise to navigate the opportunities ahead. In 2023, we identified the top scientific breakthroughs , and 2024 has even more to offer. New trends to watch include the accelerated expansion of green chemistry, the clinical validation of CRISPR, the rise of biomaterials, and the renewed progress in treating the undruggable, from cancer to neurodegenerative diseases. To hear what the experts from Lawrence Liverpool National Lab and Oak Ridge National Lab are saying on this topic, join us for a free webinar on January 25 from 10:00 to 11:30 a.m. EDT for a panel discussion on the trends to watch in 2024.

The ascension of AI in R&D

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While the future of AI has always been forward-looking, the AI revolution in chemistry and drug discovery has yet to be fully realized. While there have been some high-profile set-backs , several breakthroughs should be watched closely as the field continues to evolve. Generative AI is making an impact in drug discovery , machine learning is being used more in environmental research , and large language models like ChatGPT are being tested in healthcare applications and clinical settings.

Many scientists are keeping an eye on AlphaFold, DeepMind’s protein structure prediction software that revolutionized how proteins are understood. DeepMind and Isomorphic Labs have recently announced how their latest model shows improved accuracy, can generate predictions for almost all molecules in the Protein Data Bank, and expand coverage to ligands, nucleic acids, and posttranslational modifications . Therapeutic antibody discovery driven by AI is also gaining popularity , and platforms such as the RubrYc Therapeutics antibody discovery engine will help advance research in this area.

Though many look at AI development with excitement, concerns over accurate and accessible training data , fairness and bias , lack of regulatory oversight , impact on academia, scholarly research and publishing , hallucinations in large language models , and even concerns over infodemic threats to public health are being discussed. However, continuous improvement is inevitable with AI, so expect to see many new developments and innovations throughout 2024.

‘Greener’ green chemistry

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Green chemistry is a rapidly evolving field that is constantly seeking innovative ways to minimize the environmental impact of chemical processes. Here are several emerging trends that are seeing significant breakthroughs:

  • Improving green chemistry predictions/outcomes : One of the biggest challenges in green chemistry is predicting the environmental impact of new chemicals and processes. Researchers are developing new computational tools and models that can help predict these impacts with greater accuracy. This will allow chemists to design safer and more environmentally friendly chemicals.
  • Reducing plastics: More than 350 million tons of plastic waste is generated every year. Across the landscape of manufacturers, suppliers, and retailers, reducing the use of single-use plastics and microplastics is critical. New value-driven approaches by innovators like MiTerro that reuse industrial by-products and biomass waste for eco-friendly and cheaper plastic replacements will soon be industry expectations. Lowering costs and plastic footprints will be important throughout the entire supply chain.    
  • Alternative battery chemistry: In the battery and energy storage space, finding alternatives to scarce " endangered elements" like lithium and cobalt will be critical. While essential components of many batteries, they are becoming scarce and expensive. New investments in lithium iron phosphate (LFP) batteries that do not use nickel and cobalt have expanded , with 45% of the EV market share being projected for LFP in 2029. Continued research is projected for more development in alternative materials like sodium, iron, and magnesium, which are more abundant, less expensive, and more sustainable.
  • More sustainable catalysts : Catalysts speed up a chemical reaction or decrease the energy required without getting consumed. Noble metals are excellent catalysts; however, they are expensive and their mining causes environmental damage. Even non-noble metal catalysts can also be toxic due to contamination and challenges with their disposal. Sustainable catalysts are made of earth-abundant elements that are also non-toxic in nature. In recent years, there has been a growing focus on developing sustainable catalysts that are more environmentally friendly and less reliant on precious metals. New developments with catalysts, their roles, and environmental impact will drive meaningful progress in reducing carbon footprints.  
  • Recycling lithium-ion batteries: Lithium-ion recycling has seen increased investments with more than 800 patents already published in 2023. The use of solid electrolytes or liquid nonflammable electrolytes may improve the safety and durability of LIBs and reduce their material use. Finally, a method to manufacture electrodes without solvent s could reduce the use of deprecated solvents such as N-methylpyrrolidinone, which require recycling and careful handling to prevent emissions.

Rise of biomaterials

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New materials for biomedical applications could revolutionize many healthcare segments in 2024. One example is bioelectronic materials, which form interfaces between electronic devices and the human body, such as the brain-computer interface system being developed by Neuralink. This system, which uses a network of biocompatible electrodes implanted directly in the brain, was given FDA approval to begin human trials in 2023.

  • Bioelectronic materials: are often hybrids or composites, incorporating nanoscale materials, highly engineered conductive polymers, and bioresorbable substances. Recently developed devices can be implanted, used temporarily, and then safely reabsorbed by the body without the need for removal. This has been demonstrated by a fully bioresorbable, combined sensor-wireless power receiver made from zinc and the biodegradable polymer, poly(lactic acid).
  • Natural biomaterials: that are biocompatible and naturally derived (such as chitosan, cellulose nanomaterials, and silk) are used to make advanced multifunctional biomaterials in 2023. For example, they designed an injectable hydrogel brain implant for treating Parkinson’s disease, which is based on reversible crosslinks formed between chitosan, tannic acid, and gold nanoparticles.
  • Bioinks : are used for 3D printing of organs and transplant development which could revolutionize patient care. Currently, these models are used for studying organ architecture like 3D-printed heart models for cardiac disorders and 3D-printed lung models to test the efficacy of drugs. Specialized bioinks enhance the quality, efficacy, and versatility of 3D-printed organs, structures, and outcomes. Finally, new approaches like volumetric additive manufacturing (VAM) of pristine silk- based bioinks are unlocking new frontiers of innovation for 3D printing.

To the moon and beyond

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The global Artemis program is a NASA-led international space exploration program that aims to land the first woman and the first person of color on the Moon by 2025 as part of the long-term goal of establishing a sustainable human presence on the Moon. Additionally, the NASA mission called Europa Clipper, scheduled for a 2024 launch, will orbit around Jupiter and fly by Europa , one of Jupiter’s moons, to study the presence of water and its habitability. China’s mission, Chang’e 6 , plans to bring samples from the moon back to Earth for further studies. The Martian Moons Exploration (MMX) mission by Japan’s JAXA plans to bring back samples from Phobos, one of the Mars moons. Boeing is also expected to do a test flight of its reusable space capsule Starliner , which can take people to low-earth orbit.

The R&D impact of Artemis extends to more fields than just aerospace engineering, though:

  • Robotics: Robots will play a critical role in the Artemis program, performing many tasks, such as collecting samples, building infrastructure, and conducting scientific research. This will drive the development of new robotic technologies, including autonomous systems and dexterous manipulators.
  • Space medicine: The Artemis program will require the development of new technologies to protect astronauts from the hazards of space travel, such as radiation exposure and microgravity. This will include scientific discoveries in medical diagnostics, therapeutics, and countermeasures.
  • Earth science: The Artemis program will provide a unique opportunity to study the Moon and its environment. This will lead to new insights into the Earth's history, geology, and climate.
  • Materials science: The extreme space environment will require new materials that are lightweight, durable, and radiation resistant. This will have applications in many industries, including aerospace, construction, and energy.
  • Information technology: The Artemis program will generate a massive amount of data, which will need to be processed, analyzed, and shared in real time. This will drive the development of new IT technologies, such as cloud computing, artificial intelligence, and machine learning.

The CRISPR pay-off

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After years of research, setbacks, and minimal progress, the first formal evidence of CRISPR as a therapeutic platform technology in the clinic was realized. Intellia Therapeutics received FDA clearance to initiate a pivotal phase 3 trial of a new drug for the treatment of hATTR, and using the same Cas9 mRNA, got a new medicine treating a different disease, angioedema. This was achieved by only changing 20 nucleotides of the guide RNA, suggesting that CRISPR can be used as a therapeutic platform technology in the clinic.

The second great moment for CRISPR drug development technology came when Vertex and CRISPR Therapeutics announced the authorization of the first CRISPR/Cas9 gene-edited therapy, CASGEVY™, by the United Kingdom MHRA, for the treatment of sickle cell disease and transfusion-dependent beta-thalassemia. This was the first approval of a CRISPR-based therapy for human use and is a landmark moment in realizing the potential of CRISPR to improve human health.

In addition to its remarkable genome editing capability, the CRISPR-Cas system has proven to be effective in many applications, including early cancer diagnosis . CRISPR-based genome and transcriptome engineering and CRISPR-Cas12a and CRISPR-Cas13a appear to have the necessary characteristics to be robust detection tools for cancer therapy and diagnostics. CRISPR-Cas-based biosensing system gives rise to a new era for precise diagnoses of early-stage cancers.

MIT engineers have also designed a new nanoparticle DNA-encoded nanosensor for urinary biomarkers that could enable early cancer diagnoses with a simple urine test. The sensors, which can detect cancerous proteins, could also distinguish the type of tumor or how it responds to treatment.

Ending cancer

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The immuno-oncology field has seen tremendous growth in the last few years. Approved products such as cytokines, vaccines, tumor-directed monoclonal antibodies, and immune checkpoint blockers continue to grow in market size. Novel therapies like TAC01-HER2 are currently undergoing clinical trials. This unique therapy uses autologous T cells, which have been genetically engineered to incorporate T cell Antigen Coupler (TAC) receptors that recognize human epidermal growth factor receptor 2 (HER2) presence on tumor cells to remove them. This could be a promising therapy for metastatic, HER2-positive solid tumors.

Another promising strategy aims to use the CAR-T cells against solid tumors in conjunction with a vaccine that boosts immune response. Immune boosting helps the body create more host T cells that can target other tumor antigens that CAR-T cells cannot kill.

Another notable trend is the development of improved and effective personalized therapies. For instance, a recently developed personalized RNA neoantigen vaccine, based on uridine mRNA–lipoplex nanoparticles, was found effective against pancreatic ductal adenocarcinoma (PDAC). Major challenges in immuno-oncology are therapy resistance, lack of predictable biomarkers, and tumor heterogenicity. As a result, devising novel treatment strategies could be a future research focus.

Decarbonizing energy

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Multiple well-funded efforts are underway to decarbonize energy production by replacing fossil fuel-based energy sources with sources that generate no (or much less) CO2 in 2024.

One of these efforts is to incorporate large-scale energy storage devices into the existing power grid. These are an important part of enabling the use of renewable sources since they provide additional supply and demand for electricity to complement renewable sources. Several types of grid-scale storage that vary in the amount of energy they can store and how quickly they can discharge it into the grid are under development. Some are physical (flywheels, pumped hydro, and compressed air) and some are chemical (traditional batteries, flow batteries , supercapacitors, and hydrogen ), but all are the subject of active chemistry and materials development research. The U.S. government is encouraging development in this area through tax credits as part of the Inflation Reduction Act and a $7 billion program to establish regional hydrogen hubs.

Meanwhile, nuclear power will continue to be an active R&D area in 2024. In nuclear fission, multiple companies are developing small modular reactors (SMRs) for use in electricity production and chemical manufacturing, including hydrogen. The development of nuclear fusion reactors involves fundamental research in physics and materials science. One major challenge is finding a material that can be used for the wall of the reactor facing the fusion plasma; so far, candidate materials have included high-entropy alloys and even molten metals .

Neurodegenerative diseases

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Neurodegenerative diseases are a major public health concern, being a leading cause of death and disability worldwide. While there is currently no cure for any neurodegenerative disease, new scientific discoveries and understandings of these pathways may be the key to helping patient outcomes.

  • Alzheimer’s disease: Two immunotherapeutics have received FDA approval to reduce both cognitive and functional decline in individuals living with early Alzheimer's disease. Aducannumab (Aduhelm®) received accelerated approval in 2021 and is the first new treatment approved for Alzheimer’s since 2003 and the first therapy targeting the disease pathophysiology, reducing beta-amyloid plaques in the brains of early Alzheimer’s disease patients. Lecanemab (Leqembi®) received traditional approval in 2023 and is the first drug targeting Alzheimer’s disease pathophysiology to show clinical benefits, reducing the rate of disease progression and slowing cognitive and functional decline in adults with early stages of the disease.
  • Parkinson’s disease: New treatment modalities outside of pharmaceuticals and deep brain stimulation are being researched and approved by the FDA for the treatment of Parkinson’s disease symptoms. The non-invasive medical device, Exablate Neuro (approved by the FDA in 2021), uses focused ultrasound on one side of the brain to provide relief from severe symptoms such as tremors, limb rigidity, and dyskinesia. 2023 brought major news for Parkinson’s disease research with the validation of the biomarker alpha-synuclein. Researchers have developed a tool called the α-synuclein seeding amplification assay which detects the biomarker in the spinal fluid of people diagnosed with Parkinson’s disease and individuals who have not shown clinical symptoms.
  • Amyotrophic lateral sclerosis (ALS): Two pharmaceuticals have seen FDA approval in the past two years to slow disease progression in individuals with ALS. Relyvrio ® was approved in 2022 and acts by preventing or slowing more neuron cell death in patients with ALS. Tofersen (Qalsody®), an antisense oligonucleotide, was approved in 2023 under the accelerated approval pathway. Tofersen targets RNA produced from mutated superoxide dismutase 1 (SOD1) genes to eliminate toxic SOD1 protein production. Recently published genetic research on how mutations contribute to ALS is ongoing with researchers recently discovering how NEK1 gene mutations lead to ALS. This discovery suggests a possible rational therapeutic approach to stabilizing microtubules in ALS patients.

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  3. Working from Home: Factors that Influence Employees' Productivity

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  1. PDF WORKING PAPER Work from Home & Productivity: Evidence from Personnel

    employees who work from home state that they are about as productive as in the o ce (Etheridge et al.,2020). Those who perceive declines also experience lower levels of well-being from WFH. Bellmann and Hu bler(2020) nd that working remotely has no long-run e ect on work-life balance,

  2. (PDF) Researchers working from home: Benefits and challenges

    As a first step, the present paper explored how. working from home affects researchers' efficiency and well-being. Our results showed that while the pandemic-related lockdown decreased the work ...

  3. (PDF) The Impact of Work-from-Home on Employee Performance and

    Abstract and Figures. During the COVID-19 pandemic, working from home has unquestionably become one of the most extensively employed techniques to minimize unemployment, keep society operating ...

  4. PDF Working from Home during COVID-19: Evidence from Time-Use Studies

    We designed a time-use survey to study whether and how the transition towards "work-. from-home" arrangements (WFH), and away from the office, caused by the COVID-19. pandemic affected the use of time of knowledge workers. Specifically, this study. addresses the following research questions:

  5. Working from Home and Changes in Work Characteristics during COVID-19

    Note: Results are based on generalized ordered logit models, where the dependent variable (e.g., perceived change in flexibility) is measured with three categories: 1 = decreased, 2 = same, and 3 = increased (see the supplemental file for detail). The figure plots the average marginal effects of working from home all or most of the time relative to commuters (vertical line).

  6. Working from home: Findings and prospects for further research

    The phenomenon of working from home (WFH) is linked to a variety of megatrends that companies have confronted over many years. These include demographic change, leading to shortages of skilled workers in many regions and professions; the individualisation of needs and lifestyles as a result of changing values; and most particularly, the digitalisation of the world of work (Schmoll and Süß ...

  7. PDF How Hybrid Working From Home Works Out

    Hybrid working from home (hybrid), whereby employees work a mix of days at home and at work each week, has become common for graduate employees. This paper evaluates a randomized control trial of hybrid on 1612 graduate engineers, marketing and finance employees of a large technology firm. There are four key results.

  8. PDF Working from home

    2.1 What influences workers' preferences to work from home? 22 2.2 What do employers consider? 26 2.3 Reconciling preferences: testing, negotiation, reallocation and learning 29 2.4 The longer term 35 3. The role of regulation in the transition to a work-from-home world 37 3.1 Work health and safety 38 3.2 The workplace relations framework 47 4.

  9. PDF Work from Home After the COVID-19 Outbreak

    Taking the Dingel and Neiman (2020) estimates of the potential for home-based work, this suggests that 70.3 percent of the pre-COVID workforce who could work entirely from home did so in May. In practice, the 70.3 percent estimate of the ratio of e ective to potential home workers in May is likely a lower bound.

  10. Working from home: Findings and prospects for further research

    Central issues around the organisational and societal phenomenon of working from home are linked to the resources and strains of employees. This has direct consequences for the leadership and management of human resources. In this article, we review the results of research contributions available in this issue and at the same time show that ...

  11. PDF Why Working from Home Will Stick

    Second, the shift to WFH will directly reduce spending in major city centers by at least 5-10 percent relative to the pre-pandemic situation. Third, our data on employer plans and the relative productivity of WFH imply a 5 percent productivity boost in the post-pandemic economy due to re-optimized working arrangements.

  12. Work from Home and Productivity: Evidence from Personnel and Analytics

    In this paper we have presented the most detailed analysis of WFH productivity changes for knowledge workers available to date. The paper makes a number of significant contributions. We study an occupation that is expected to be amenable to WFH, but involves significant cognitive, collaborative, and innovation tasks.

  13. PDF Working from Home Around the World

    The pandemic triggered a large, lasting shift to work from home (WFH). To study this shift, we survey full-time workers who finished primary school in 27 countries as of mid 2021 and early 2022. Our cross-country comparisons control for age, gender, education, and industry and treat the U.S. mean as the baseline.

  14. (PDF) Work from home during COVID-19: Employees ...

    The first school of thought argues that in today's world home and work are two opposing forces that often lead to an imbalance when the demand from one domain, either, home, work, personal, family ...

  15. PDF "WORKING" REMOTELY

    utset of the pandemic.5In two surveys of 2,207 remote workers, 32% report wanting to remain fully remote after the pandemic and 56% report wanting to work remotely for more than half their week (PwC, 2020; orning Consult, 2020). Similarly, in a ZipRecruiter survey, 45% say they want a job that would let them.

  16. Work from Home and Productivity: Evidence from Personnel and ...

    Abstract. We study employee productivity (output per hour worked) before and during the working from home [WFH] period of the Covid-19 pandemic, using personnel and analytics data from over 10,000 skilled professionals at a large Asian IT services company.

  17. PDF Work from Home After the COVID-19 Outbreak

    Abstract. Based on rich novel survey data, we document that 35.2 percent of the US workforce worked entirely from home in May 2020, up from 8.2 percent in February. Highly educated, high-income and white workers were more likely to shift to working from home and maintain employment following the pandemic.

  18. PDF The Influence of Working from Home on Employees' Productivity

    The study results indicate that working from home has an influence on productivity of the employees. While influences of some of the factors are either positive or negative, the influence of some of the factors depend on the characteristics and attitude of the employees and the circumstances. 1. Introduction.

  19. (PDF) REMOTE WORK AND HYBRID WORK ORGANIZATIONS

    Abstract. Remote work, especially working from home, has become the most common form of work in the third decade of the 21st century. What started at the beginning of the millennium as an ...

  20. PDF WORK FROM HOME

    Findings of the research: Those who were working from home performed 13.5% more calls than those who came to the office, which is tantamount to an extra workday per week! $1,900 per employee for the nine months was saved by Ctrip on furniture and space-related cost. 50% drop in attrition rate.8.

  21. (PDF) Work from home during COVID-19: Employees perception and

    The work-from-home culture has significant effects on one's life. Fundamentally, this has changed how people live and work. Many challenges and problems were faced by people staying at home and working. Work from home confines employees to stay at home and reduces face-to-face communication which reduces the spread of Covid-19.

  22. Researchers working from home: Benefits and challenges

    The flexibility allowed by the mobilization of technology disintegrated the traditional work-life boundary for most professionals. Whether working from home is the key or impediment to academics' efficiency and work-life balance became a daunting question for both scientists and their employers. The recent pandemic brought into focus the merits and challenges of working from home on a level ...

  23. Home

    Natural Hazards is devoted to original research work on all aspects of natural hazards, including the forecasting of catastrophic events, risk management, and ...

  24. Microsoft Research

    Explore research at Microsoft, a site featuring the impact of research along with publications, products, downloads, and research careers. ... Research. Research Home ; Our research. Resources. Publications; Code & data; People; Microsoft Research blog Research areas: Intelligence. Artificial intelligence ... Chatbot teamwork makes the AI dream ...

  25. (PDF) Work from Home (WFH): The New Normal?

    mentioned in the study conducted by Su (2020) that 39% of the jobs ca n be don e from. home (Alon et al., 2020). In his article Nicho l as Bloom mentions that through WFH. 33% of in crease in ...

  26. READ: Biden-Trump debate transcript

    For example, I provided for the idea that any black family, first time home buyer should get a $10,000 tax credit to be able to buy their first home so they can get started.

  27. Scientific breakthroughs: 2024 emerging trends to watch

    After years of research, setbacks, and minimal progress, the first formal evidence of CRISPR as a therapeutic platform technology in the clinic was realized. Intellia Therapeutics received FDA clearance to initiate a pivotal phase 3 trial of a new drug for the treatment of hATTR, and using the same Cas9 mRNA, got a new medicine treating a different disease, angioedema.